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  • 1
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    Chromosome mapping and expression of a putative testis-determining gene in mouse (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-01-06
    Description: Isolation and mapping of a mouse complementary DNA sequence (mouse Y-finger) encoding a multiple, potential zinc-binding, finger protein homologous to the candidate human testis-determining factor gene is reported. Four similar sequences were identified in Hind III-digested mouse genomic DNA. Two (7.2 and 2.0 kb) were mapped to the Y chromosome. Only the 2.0-kb fragment, however, was correlated with testis determination. Polymerase chain reaction analysis suggests both Y loci are transcribed in adult testes. A 3.6-kb fragment was mapped to the X chromosome between the T16H and T6R1 translocation breakpoints, and a fourth (6.0 kb) was mapped to chromosome 10. Hence, mYfin sequences have been duplicated several times in the mouse, although they are not duplicated in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nagamine, C M -- Chan, K M -- Kozak, C A -- Lau, Y F -- N01-CB-25584/CB/NCI NIH HHS/ -- New York, N.Y. -- Science. 1989 Jan 6;243(4887):80-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2563174" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Chromosome Mapping ; DNA-Binding Proteins/genetics ; *Genes ; Male ; Metalloproteins/genetics ; Mice ; Nucleic Acid Hybridization ; Polymorphism, Restriction Fragment Length ; *Sex Determination Analysis ; Testis/*anatomy & histology ; *Transcription, Genetic ; X Chromosome ; Y Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5 (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: By means of an approach that combined the techniques of somatic cell genetics and Mendelian breeding studies, the inducibility locus, designated Cv, for ecotropic murine leukemia virus in BALB/c mice, was mapped to chromosome 5, 23 units from the locus for phosphoglucomutase-1, with gene order Cv-Pgm-1-Gus. This low-efficiency inducibility locus is therefore not allelic with the chromosome 7 loci previously described for two other mouse strains with high virus inducibility. These studies provide further evidence that endogenous ecotropic viruses represent viral genomes inserted at different chromosomal sites in the various mouse strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kozak, C A -- Rowe, W P -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219475" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Genes, Viral ; Genetic Linkage ; Hybrid Cells/microbiology ; Leukemia Virus, Murine/*genetics ; Mice ; Mice, Inbred BALB C/*microbiology ; Phosphoglucomutase/metabolism ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-26
    Description: The mouse homolog (c-sis) of the transforming gene of the simian sarcoma virus was mapped to chromosome 15 by the Southern blot analysis of DNA's from hamster-mouse somatic cell hybrids. Alterations in c-sis expression may thus play a role in the various murine neoplastic diseases characterized by rearrangements or duplications of chromosome 15.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kozak, C A -- Sears, J F -- Hoggan, M D -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):867-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308764" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Aberrations/genetics ; Chromosome Disorders ; Chromosome Mapping ; Leukemia, Experimental/*genetics ; Mice ; Nucleic Acid Hybridization ; *Oncogenes ; Retroviridae/*genetics ; Sarcoma Virus, Woolly Monkey/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Assignment of the genes for thymidine kinase and galactokinase toMus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids (1977)
    Springer
    Somatic cell and molecular genetics 3 (1977), S. 121-133 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Somatic cell genetic techniques were used to establish linkage assignments for the loci coding for galactokinase (GLK) and thymidine kinase (TK) in the laboratory mouse, Mus musculus.Four fusion experiments produced cell hybrids that segregated mouse chromosomes. Three series of hybrid clones were produced from the fusion of mouse macrophages or fibroblasts and Chinese hamster cells of the E36 line, which is deficient in hypoxanthine phosphoribosyltransferase activity. Clones were assayed for the expression of 11 mouse isozymes coded by genes on 11 chromosomes. Ten isozymes were retained at high frequencies, but the mouse GLK phenotype was absent in most primary clones and all secondary clones. Chromosome analysis of 24 of these hybrids indicated that GLK activity was lost concordantly with chromosome 11. One hybrid clone was produced from the fusion of peritoneal macrophages and hamster cells of the a3 line, which lacks TK activity. Mouse GLK activity was expressed in this primary clone and all secondary clones isolated in HAT medium, and was lost in all secondary clones backselected in medium with 5-bromodeoxyuridine. Thus, the genes coding for GLK and TK are syntenic and both can be assigned to chromosome 11. The absence of chromosome 11 in the related series of a3 hybrids, and its rapid segregation in 3 series of E36 hybrids, suggests that it carries a third locus (or loci), the retention of which is detrimental to Chinese hamster/mouse hybrids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01551809
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  • 5
    Electronic Resource
    Electronic Resource
    Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids (1979)
    Springer
    Biochemical genetics 17 (1979), S. 23-34 
    Details
    ISSN: 1573-4927
    Keywords: ouabain ; microcells ; gene mapping ; somatic cell genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Human/mouse microcell hybrids were used to establish the assignment of the gene governing resistance to the cardiac glycoside ouabain (Oua-1) to Mus musculus chromosome 3. Microcells were prepared from primary mouse embryo fibroblasts and fused with HeLa S3 cells, and microcell hybrids were isolated and maintained in medium containing 10−6 m ouabain. Resistance to ouabain was not expressed concordantly with any of 26 murine isozyme markers. Karyotypic analysis of five primary clones showed that one to five murine chromosomes had been transferred from donor to recipient in these experiments. Only mouse chromosome 3 was common to all ouabain-resistant primary clones. Both ouabain-resistant and -sensitive subclones were isolated from hybrids grown in the absence of selective pressure, and karyotyping showed that loss of resistance to ouabain was concordant with the loss of murine chromosome 3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484471
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  • 6
    Electronic Resource
    Electronic Resource
    Murine bone sialoprotein (BSP): cDNA cloning, mRNA expression, and genetic mapping (1994)
    Springer
    Mammalian genome 5 (1994), S. 108-111 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292337
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  • 7
    Electronic Resource
    Electronic Resource
    The gene for mouse p58cdc2L1 (Cdc2l1) protein kinase maps to distal mouse Chromosome 4 (1994)
    Springer
    Mammalian genome 5 (1994), S. 191-192 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352357
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  • 8
    Electronic Resource
    Electronic Resource
    The Myb and Ahi-1 genes are physically very closely linked on mouse Chromosome 10 (1994)
    Springer
    Mammalian genome 5 (1994), S. 142-148 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ahi-1 has previously been identified as a common helper provirus integration site on mouse Chromosome (Chr) 10 in 16% of Abelson pre-B-cell lymphomas and shown to be closely linked to the Myb protooncogene. By using long-range restriction mapping, we have mapped the Myb and Ahi-1 regions within a 120-kbp DNA fragment. The Ahi-1 region is located approximately 35 kbp downstream of the Myb gene. A further comfirmation of this finding was obtained by screening a mouse YAC library. The three positive clones obtained contained both the Myb and Ahi-1 gene sequences. To test whether provirus integration in the Ahi-1 region enhances the expression of Myb by a cis-acting mechanism, we have also examined Myb gene expression in A-MuLV-induced pre-B-lymphomas. Our data have revealed that there is no clear evidence for such activation in the tumors we have tested, indicating that provirus insertion in the Ahi-1 region is activating a novel gene, apparently involved in tumor formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352344
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  • 9
    Electronic Resource
    Electronic Resource
    Genetic mapping of the gene encoding guanylate cyclase-A/atrial natriuretic factor receptor (Npra) to mouse Chromosome 3 (1994)
    Springer
    Mammalian genome 5 (1994), S. 520-522 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369325
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  • 10
    Electronic Resource
    Electronic Resource
    Mouse tetranectin: cDNA sequence, tissue-specific expression, and chromosomal mapping (1995)
    Springer
    Mammalian genome 6 (1995), S. 693-696 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Tetranectin is a plasminogen-binding tetrameric protein originally isolated from plasma. Expression of tetranectin appears ubiquitous, although particularly high expression is noted in the stroma of malignant tumors and during mineralization. To dissect the molecular basis of tetranectin gene regulation, mouse tetranectin cDNA was cloned from a 16-day-old mouse embryo library. Sequence analysis revealed a 992-bp cDNA with an open reading frame of 606 bp, which is identical in length to the human tetranectin cDNA. The deduced amino acid sequence showed high homology to the human cDNA with 76% identity and 87% similarity at the amino acid level. Sequence comparisons between mouse and human tetranectin and some C-type lectins confirmed a complete conservation in the position of six cysteines as well as numerous other amino acid residues, indicating an essential structure for potential function(s) of tetranectin. The sequence analysis revealed a difference in both sequence and size of the noncoding regions between mouse and human cDNAs. Northern analysis of the various tissues from mouse, rat, and cow showed the major transcript(s) to be approximately 1 kb, which is similar in size to that observed in human. Although additional minor bands of 1.5 and 3.3 kb were found in Northern blots, RT-PCR (reverse transcription polymerase chain reaction) analysis failed to provide evidence that these minor bands are products of the tetranectin gene. Finally, the genetic map location for this gene, Tna, was determined to be on distal mouse Chromosome (Chr) 9 by analysis of two sets of multilocus crosses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00354289
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