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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of clinical monitoring and computing 11 (1995), S. 311-316 
    ISSN: 1573-2614
    Keywords: Intubation: endotracheal? esophageal ; Monitoring: carbon dioxide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Medicine
    Notes: Abstract Objective. The esophageal-tracheal Combitube (Sheridan, Inc., Argyle, NY) is a unique double lumen tube that has been introduced as an emergency intubation device. Since it is placed blindly, proper use requires determination of which lumen can be successfully used for ventilation. The Easycap (Nellcor, Inc., Pleasanton, CA) is a colorimetric carbon dioxide detector that reacts with exhaled gas to indicate proper tracheal tube location. The purpose of this study was to determine if the Easycap can be used to identify which Combitube lumen is patent to the trachea after blind placement in dogs.Methods and Results. The study was conducted using 8 anesthetized dogs. In each of 15 blind insertions of the Combitube, the Easycap device responded appropriately by changing color from purple to yellow when connected to the lumen communicating with the trachea. When the Easycap device was connected to the alternate lumen, no color change was appropriately observed in 9 out of 15 cases (60%) after 6 breaths; in 4 of the remaining 6 (87%, total), no color change was noted after 12 breaths. In the 2 remaining cases, the color change indicated the need for further verification of the tube location. In separate experiments, 10 direct tracheal and esophageal insertions of the Combitube were correctly verified by the appropriate Easycap color change.Conclusions. Our results suggest that the Easycap device may be useful with the Combitube, although human data are required.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-2614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Medicine
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2016-05-25
    Description: Article HIV evolves within infected persons to escape being destroyed by the immune system. Here, Barton et al . combine evolutionary dynamics and statistical physics to simulate this process, successfully predicting the relative rate and location of escape mutations in viral sequences for a cohort of HIV-infected persons. Nature Communications doi: 10.1038/ncomms11660 Authors: John P. Barton, Nilu Goonetilleke, Thomas C. Butler, Bruce D. Walker, Andrew J. McMichael, Arup K. Chakraborty
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 4
    Publication Date: 2011-08-24
    Description: A patent foramen ovale (PFO) has been reported to be an important risk factor for cardioembolic cerebrovascular accidents through paradoxical systemic embolization, and it provides one potential mechanism for the paradoxical systemic embolization of venous gas bubbles produced after altitude or hyperbaric decompressions. Here, we present in a single document a summary of the original findings and views from authors in this field. It is a comprehensive review of 145 peer-reviewed journal articles related to PFO that is intended to encourage reflection on PFO detection methods and on the possible association between PFO and stroke. There is a heightened debate on whether aviators, astronauts, and scuba divers should go through screening for PFO. Because it is a source of an important controversy, we prefer to present the findings in the format of a neutral bibliographic review independent of our own opinions. Each cited peer-reviewed article includes a short summary in which we attempt to present potential parallels with the pathophysiology of decompression bubbles. Two types of articles are summarized, as follows. First, we report the original clinical and physiological findings which focus on PFO. The consistent reporting sequence begins by describing the method of detection of PFO and goal of the study, followed by bulleted results, and finally the discussion and conclusion. Second, we summarize from review papers the issues related only to PFO. At the end of each section, an abstract with concluding remarks based on the cited articles provides guidelines.
    Keywords: Aerospace Medicine
    Type: Aviation, space, and environmental medicine (ISSN 0095-6562); Volume 74; 6 Pt 2; B1-64
    Format: text
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  • 5
    Publication Date: 2019-06-28
    Description: The purpose of this study was to investigate the hypothesis that reduced joint/muscle activity (hypo kinesia) as well as reduced or null loading of limbs (adynamia) in gravity would result in reduced decompression-induced gas phase and symptoms of decompression sickness (DCS). Finding a correlation between the two phenomena would correspond to the proposed reduction in tissue gas phase formation in astronauts undergoing decompression during extravehicular activity (EVA) in microgravity. The observation may further explain the reported low incidence of DCS in space.
    Keywords: Life Sciences (General)
    Type: NASA/CR-97-206457 , NAS 1.26:206457
    Format: application/pdf
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  • 6
    Publication Date: 2019-07-17
    Description: We evaluate 2-hour prebreathe protocols combining simulated microgravity and exercise during prebreathe with the objective of validating a protocol for use on International Space Station (ISS). The protocol was tested with four different exercise doses during prebreathe in a multi-center trial involving three laboratories. Subject selection, Doppler monitoring techniques for venous gas emboli (VGE), test termination criteria, and definitions of decompression sickness (DCS) were standardized in all laboratories. The Phase II protocol met the accept criteria for a prebreathe procedure for use by astronauts during assembly and maintenance of the ISS Dual-cycle ergometry or light exercise individually was not sufficient to protect against DCS at acceptable levels. The combination of both was successful.
    Keywords: Aerospace Medicine
    Type: May 14, 2000 - May 18, 2000; Houston, TX; United States
    Format: text
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  • 7
    Publication Date: 2019-07-13
    Description: Current therapy for massive venous air embolism (VAE) includes the use of the left lateral recumbent (LLR) position. This recommendation is based on animal studies, conducted 50 years ago, which looked primarily at survival. Little is known, however, about the concomitant hemodynamic response after VAE in various body positions. The purpose of this study was to investigate the hemodynamic and cardiovascular changes in various body positions after VAE. Twenty-two mechanically ventilated supine mongrel dogs received a venous air infusion of 2.5 mL/kg at a rate of 5 mL/s. One minute after the infusion, 100% oxygen ventilation was commenced and the body position of the dogs was changed to either the LLR (n = 6), the LLR with the head 10 deg down (LLR-10 deg; n = 6) or the right lateral recumbent (RLR; n = 5) position. Five dogs were maintained in the supine position (SUP; n = 5). One dog died in every group except in the SUP group, where all the dogs recovered. There were no significant differences among the various body positions in terms of heart rate, mean arterial pressure, pulmonary artery pressure, central venous pressure, left ventricular end-diastolic pressure, or cardiac output. The acute hemodynamic changes occurring during the first 5-15 min after VAE recovered to 80% of control within 60 min. Our data suggest that body repositioning does not influence the cardiovascular response to VAE. Specifically, our data do not support the recommendation of repositioning into the LLR position for the treatment of VAE.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: NASA-CR-200031 , NAS 1.26:200031 , NIPS-96-07275 , (ISSN 0003-2999)
    Format: application/pdf
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  • 8
    Publication Date: 2019-07-12
    Description: The effect of Trendelenburg position (TP) on the distribution of arterial air emboli in dogs was examined in a two-part investigation. In the first part, the effects of the bubble size and the vessel angle on the bubble velocity and the direction of flow were investigated in vitro, using a simulated carotid artery preparation. It was found that larger bubbles increased in velocity in the same direction as the blood flow at 0-, 10-, and 30-deg vessel angles, and decreased when the vessel was positioned at 90 deg. Smaller bubbles did not change velocity from 0 to 30 deg, but acted to increase the velocity, in the same direction as the flood flow, at 90 deg. The second series of experiments examined the effect of 0 to 30 deg TP on carotid-artery distribution of gas bubbles injected into the left ventricle or ascending aorta of anesthetized dogs. It was found that, regardless of the degree of the TP, the bubbles passed into the carotid artery simultaneously with the passage into the abdominal aorta. It is concluded that the TP does not prevent arterial bubbles from reaching the brain.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Annals of Thoracic Surgery (ISSN 0003-4975); 45; 198-202
    Format: text
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  • 9
    Publication Date: 1983-03-18
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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