Publication Date:
2011-04-13
Description:
In humans, a vast array of cytoskeletal motor proteins (19 dyneins, 43 kinesins, and 39 myosins) (1) move along microtubule and actin filament tracks to generate an enormous range of cellular functions. The kinesin and dynein motor proteins drive long-distance transport along microtubules, whereas the myosins are responsible for short-range delivery along actin filaments (2). The myosin motor proteins are composed of three functional domains: a motor domain with catalytic ATPase and actin-binding sites, a neck (lever arm with 1–6 bound calmodulins), and a cargo-binding tail domain. The mechanochemical properties of the myosins have been studied in great detail, but...
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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