ISSN:
1432-1432
Keywords:
Key words: Human mucin — Cluster — 11p15.5 — Evolution — Cys-rich domain
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract. The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. In contrast, little information is available concerning MUC6. These Cys-subdomains contain 10 cysteine residues that have a highly conserved position. We present here a coherent probable evolutionary history of this human gene family after comparison of the nucleotide sequences of these Cys-subdomains. The three MUC loci MUC2, MUC5AC, and MUC5B may have evolved from a common ancestral gene by two successive duplications. Moreover, we can postulate that MUC5AC and MUC5B have evolved in a concerted manner, while MUC2 has evolved separately.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00006276
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