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Conference on Library Work in Africa (1965)

Broome, E. M.

Cambridge : Cambridge University Press

The @journal of modern African studies 3 (1965), S. 613-614

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ISSN: 0022-278X

Source: Cambridge Journals Digital Archives

Topics: Ethnic Sciences , History , Political Science , Economics

Notes: The rapidly growing interest shown by the people of Scandinavia in the developing countries of Africa has affected librarians too. Though perhaps the Swedes were rather slower than the Danes to respond to the stimulus of the conference on public libraries in Africa held in Copenhagen in 1961, they are now attempting to recapture the initiative. The 1965 conference, organised jointly by the Swedish National Board of Education, the Scandinavian Institute of African Studies, and the Norrköping City Library, was designed as a springboard for further action.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1017/S0022278X00006558

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Role of apoptosis and apoptosis-related proteins in the cisplatin-resistant phenotype of human tumor cell lines (1997)

Perego, P. ; Righetti, S. C. ; Supino, R. ; [et al.]

Springer

Apoptosis 2 (1997), S. 540-548

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ISSN: 1573-675X

Keywords: Apoptosis ; bcl-2 ; cisplatin resistance ; p53

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Since apoptosis is the primary mode of cell death induced by cisplatin, the role of apoptosis and apoptosis-related gene products in cisplatin resistance was investigated in four human cisplatin-resistant cell lines of different tumour type. A common feature of the resistant sublines was a reduced susceptibility to drug-induced apoptosis compared to parental sensitive lines. Loss of wild-type p53 function was not a general event associated with the development of drug resistance. An increased bcl-2 expression was found in resistant cells characterized by mutant p53 (A431/Pt and IGROV-1/Pt), whereas in osteosarcoma (U2-OS/Pt) and in ovarian carcinoma (A2780/CP) cells with wild-type p53, bcl-2 levels were markedly reduced. U2-OS/Pt cells had a 16-fold increase in the level of Bcl-xL protein. Stable transfection of U2-OS cells with bcl-xL cDNA conferred a low level of drug resistance to cisplatin, suggesting that overexpression of this gene contributes to the ci splatin-resistant phenotype of this osteosarcoma cell system. In conclusion, these observations suggest a variable contribution of apoptosis-related genes to cisplatin resistance depending on the biological background of the cell system and presumably reflecting different pathways of apoptosis.