ISSN:
1573-0832
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Adherence of Candida albicans to buccal epithelial cells of newborn infants was studied by the visual adherence method. Forty-five samples of buccal epithelial cells were obtained from 21 normal newborns at different times following delivery. In group 1 (mean age 7.5 hr) 367±51 yeast cells adhered to 100 epithelial cells. In group 2 (mean age 2.3 days) 384±36 yeast cells adhered to 100 cells. In group 3 (mean age 6.2 days) 488±57 yeast cells adhered to 100 cells. Differences among the groups were not significant (p〉0.1). A significant difference was found in the percentage of epithelial cells binding 10 yeast cells between group 1 (7.25±0.9) and group 3 (14.9±2.5), and group 2 (8.0±2.0) and group 3 (p⩽0.025). In 12 infants studied twice at mean age of 2.1 and 6.3 days (included in groups 2 and 3) a significant increase was found in the number of adherent yeasts binding to 100 epithelial cells (330±87 and 485±52 respectively) (p⩽0.03), and in the percentage of epithelial cells binding ⩾10 yeast cells (5.0±3.0 and 14.7±3.5 respectively, p⩽0.004) for each infant. The age-related increased affinity of buccal epithelial cells to Candida albicans may have relevance in the development of oral thrush.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00440948
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