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  • 1
    Monograph available for loan
    Monograph available for loan
    Inside Science : a preliminary investigation of the case of global warming (1996)
    Hamburg : Max-Planck-Institut für Meteorologie
    Associated volumes
    Details Availability
    Call number: ZSP-686-195
    In: Report
    Type of Medium: Monograph available for loan
    Pages: 58 S. : graph. Darst. : 29 cm
    ISSN: 0937-1060
    Series Statement: Report / Max-Planck-Institut für Meteorologie 195
    Branch Library: GFZ Library
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  • 2
    Electronic Resource
    Electronic Resource
    SIGNALING COMPLEXES:Biophysical Constraints on Intracellular Communication (1998)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 27 (1998), S. 59-75 
    Details
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Abstract This review surveys the kinds of protein complex that participate in cell communication and identifies, where possible, general principles by which they form and act. It also advances the notion that biophysical constraints imposed by macromolecular crowding and diffusion have had a controlling influence on the evolution of cell signaling pathways. Complexes associated with the bacterial aspartate receptor, with eucaryotic tyrosine kinase receptors, with T-cell receptors, and with focal contacts are examined together with proteins that serve as adaptors, anchors, and scaffolds for signaling complexes. The importance of diffusion in controlling the numbers and locations of signaling complexes is discussed, as is the special role played by membranes in signaling pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biophys.27.1.59
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  • 3
    Electronic Resource
    Electronic Resource
    CONFORMATIONAL SPREAD: The Propagation of Allosteric States in Large Multiprotein Complexes (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 33 (2004), S. 53-73 
    Details
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: The phenomenon of allostery is conventionally described for small symmetrical oligomeric proteins such as hemoglobin. Here we review experimental evidence from a variety of systems-including bacterial chemotaxis receptors, muscle ryanodine receptors, and actin filaments-showing that conformational changes can also propagate through extended lattices of protein molecules. We explore the statistical mechanics of idealized linear and two-dimensional arrays of allosteric proteins and show that, as in the analogous Ising models, arrays of closely packed units can show large-scale integrated behavior. We also discuss proteins that undergo conformational changes driven by the hydrolysis of ATP and give examples in which these changes propagate through linear chains of molecules. We suggest that conformational spread could provide the basis of a solid-state "circuitry" in a living cell, able to integrate biochemical and biophysical events over hundreds of protein molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biophys.33.110502.132703
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  • 4
    Electronic Resource
    Electronic Resource
    Cytochalasin action (1979)
    [s.l.] : Nature Publishing Group
    Nature 282 (1979), S. 671-671 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] CERTAIN chemicals have come to stand for particular areas of biological research. Think of fluorescein isothiocyanate; 2-deoxyglucose; bis-acrylamide; a-bung-arotoxin, anti-mouse immunoglobulin. Substances such as these are hitched so firmly to a line of research that you could almost use their ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/282671a0
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  • 5
    Electronic Resource
    Electronic Resource
    Stops and starts in microtubules (1979)
    [s.l.] : Nature Publishing Group
    Nature 280 (1979), S. 537-537 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE conventional wisdom that micro-tubules run the entire length of nerve axons and dendrites probably comes from a paper by Weiss and Mayr (Acta Neuropath, supp V, 198; 1971). On page 200 these authors conclude that "each tubule is a single unitary entity, extending in uninterrupted and undivided ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/280537a0
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  • 6
    Electronic Resource
    Electronic Resource
    Gel motility (1977)
    [s.l.] : Nature Publishing Group
    Nature 270 (1977), S. 560-561 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] LIKE the electron, the cell shows a different face according to how it is treated; at least, that is the conclusion to be drawn from recent papers on cell movement. Even the intuitive picture of the inside of the cell seems to depend on the techniques used. To the biochemist for example, who ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/270560a0
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  • 7
    Electronic Resource
    Electronic Resource
    Cell motility: Particle transport (1983)
    [s.l.] : Nature Publishing Group
    Nature 304 (1983), S. 683-683 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ONE of the most astonishing facts about the intracellular movement of membranous organelles is that we still do not know what drives them. We cannot say, at present, whether the particle we see in the light microscope, moving steadily from one side of a cell to the other, is being driven by a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/304683a0
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  • 8
    Electronic Resource
    Electronic Resource
    Cells come of age (1986)
    [s.l.] : Nature Publishing Group
    Nature 320 (1986), S. 117-117 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] REVIEWING reviews can be a vertiginous business, especially in a field such as cell biology in which any single experimental observation may be caught up and reflected from a ramifying literature, like images in a Hall of Mirrors. On the red blood cell cytoskeleton, for example, you will have a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/320117a0
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  • 9
    Electronic Resource
    Electronic Resource
    Rapid transport of foreign particles microinjected into crab axons (1983)
    [s.l.] : Nature Publishing Group
    Nature 303 (1983), S. 718-720 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Single giant axons were dissected from the walking legs of the shore crab C. maenas and mounted for observation in Petri dishes with coverslip inserts in a buffer resembling their internal ionic composition (400 mM K glutamate, 150mM glycine, 10 mM EGTA, 20 mM HEPES pH 7.2, 5 mM MgCl2), as pre ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/303718a0
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  • 10
    Electronic Resource
    Electronic Resource
    Cell biology: Computer modelling of the behaviour of actin gels (1985)
    [s.l.] : Nature Publishing Group
    Nature 313 (1985), S. 738-738 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] UNDERSTANDING certain kinds of cell movements may require the use of a computer, to judge from two recently published papers by theoretical biologists G.M. Odell1 and G.F. Oster2. This applies especially to the slow amoeboid movements of animal cells as they crawl over surfaces, engulf large ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/313738a0
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