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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2019
    Description: 〈p〉Despite being a minor component of cells, phosphoinositides are essential for eukaryotic membrane biology, serving as markers of organelle identity and involved in several signaling cascades. Their many functions, combined with alternative synthesis pathways, make in vivo study very difficult. In vitro studies are limited by their inability to fully recapitulate the complexities of membranes in living cells. We engineered the biosynthetic pathway for the most abundant phosphoinositides into the bacterium 〈i〉Escherichia coli〈/i〉, which is naturally devoid of this class of phospholipids. These modified 〈i〉E. coli〈/i〉, when grown in the presence of 〈i〉myo〈/i〉-inositol, incorporate phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PI4P), phosphatidylinositol-4,5-bisphosphate (PIP2), and phosphatidylinositol-3,4,5-trisphosphate (PIP3) into their plasma membrane. We tested models of biophysical mechanisms with these phosphoinositides in a living membrane, using our system to evaluate the role of PIP2 in nonconventional protein export of human basic fibroblast growth factor 2. We found that PI alone is sufficient for the process. 〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 2
    Publication Date: 2021-05-19
    Description: La gestión costera integrada es el enfoque más reconocido mundialmente para el ordenamiento de zonas costeras. En este contexto, se realizó la zonificación de manejo en el golfo de Cupica, ubicado en la costa Pacífica colombiana. La metodología se basó en el levantamiento de fotos georreferenciadas (geofotos), la caracterización rápida del área de estudio y la identificación y valoración de interacciones entre los usos y actividades costeras, concluyendo con la creación de un mapa que permitió ordenar el territorio costero. Como resultado, se definieron los tipos de costa, las características sistémicas y las interacciones entre los 27 usos y actividades encontrados en el golfo de Cupica, integrados en una salida cartográfica completa. En consecuencia, se evidenció la utilidad de las tecnologías de la información y la comunicación para las tareas de ordenamiento costero, así como las técnicas de evaluación rápida. Así mismo, se destacó la matriz de interacciones costeras como una herramienta poderosa para caracterizar, diagnosticar y proponer medidas de manejo en un contexto de gestión costera integrada.
    Description: Published
    Keywords: Gestión Costera ; Zonificación ; Interacciones costeras ; Ciencias de la complejidad ; Cupica ; ASFA_2015::I::Integrated coastal zone management ; ASFA_2015::C::Coastal zone
    Repository Name: AquaDocs
    Type: Journal Contribution , Not Known
    Format: pp.105-122
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  • 3
    Publication Date: 2024-06-18
    Description: This scientometric analysis significantly advances the understanding of landslide risk assessment and economic losses, focusing on scientometric insights. This study aims at analyzing the global trends and structures of landslide risk and economic loss research from 2002 to 2023 using scientometric techniques such as co-authorship, co-word, co-citation, cluster analysis, and trend topics, among others. Thus, analysis of 92 studies gathered from Scopus and Web of Science databases reveals a continuous growth in environmental, social, and quantitative research topics. Predominant contributions hail mainly from China and Italy. The research identifies critical themes, including risk analysis, vulnerability, fragility, and economic losses. The current identified research combines advanced statistical methods, including logistic regression, with climate change scenarios and susceptibility assessments to reveal intricate connections between climatic shifts, hydrogeological hazards, and their economic and environmental impacts. This study provides researchers and practitioners with a comprehensive understanding of the status quo and research trends of ontology research landslide risk and its economic losses. It also promotes further studies in this domain.
    Type: info:eu-repo/semantics/article
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