ISSN:
1573-904X
Keywords:
suppositories
;
rectum
;
polyethylene glycol
;
triglyceride
;
monoglyceride
;
fatty acids
;
ulcer
;
hyperemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The effect of suppository bases on rabbit rectal mucosa was investigated using six triglyceride bases, polyethylene glycol, and a triglyceride base combined with monoglycerides or fatty acids and methyl esters of those acids. Rectal irritation was evaluated and scored according to defined pathological features. “Pure” triglycerides and a triglyceride to which a nonionic surfactant was added caused severe mucosal damage with ulceration and inflammation. Hyperemia was characteristic for irritation by polyethylene glycol suppositories. Mucosal damage by a pure triglyceride combined with monoglycerides or fatty acids and methyl esters of those acids was similar but statistically less pronounced than with all other bases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015828201697
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