ISSN:
1573-8221
Schlagwort(e):
transplantation of human fetal tissue (THFT)
;
treatment of hematological crises
;
gene therapy
;
transplantation of hemopoietic stem cells
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Abstract Intravenous transplantation of human fetal tissue, notably of the liver and thymus, is used in emergency hematological states: aplastic anemia and acute leukemia. The strong manifestation of “graft-versus-host” disease proved unexpected. Fetal donor hepatic cells stimulate hemopoiesis in the recipient. In some cases true cellular chimerism has been observed, specifically when a transplant of human fetal tissue (THFT) to a fetus with prenatal pathology was performedin utero. In gene therapy attempts have been made to infuse hemopoietic stem cells intravenously or to introduce the adenosine aminase gene into leukocytes of patients with a deficiency of this enzyme. Treatment using transplantation of human fetal tissue will help solve the problem of HLA-histocompatibility and will make gene therapy more widely applicable.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02444189
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