ISSN:
1573-8221
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary An attempt was made in this work to trace the dynamics of hyaluronidase distribution in the body during the development of a Brown-Pearce tumor, and the changes in the hyaluronidase level in the organs following administration of anticancer serum. Preliminary experiments on healthy animals demonstrated the absence of hyaluronidase in their blood and organ tissues. With pronounced metastases, a marked positive reaction to the presence of hyaluronidase was seen in the blood serum and extracts of various organs (liver, kidneys, gonads, etc.) of experimental animals. With gradual resorption of the tumor nodes, resulting from the action of V. A. Chepurin's cancer antiserum, the amount of hyaluronidase in the organs and tissues declined; after the resolution of the nodes, hyaluronidase disappeared completely. As time went on some changes were also noted in the other indices in connection with the cancer antiserum administration. The blood picture showed a tendency to normalization, and the loss of weight, which was initially marked, was arrested.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00788839
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