ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Synthesis of Substance P and of Acylated Partial SequencesSubstance P undecapeptide has been synthesized by the stepwise procedure and via condensation of the fragments 1-4 and 5-11. Formation of pyrrolidone carboxylic acid- and S-tert. butyl peptides was observed. Gln(Mbh)-containing sequences have been synthesized but were not useful for fragment condensation due to there low solubility. Additionally, some derivatives have been prepared by acylation of the C-terminal pentapeptide. Reaction with trifluoracetic acid anhydride resulted in the formation of substituted 5-amino-oxazole derivatives as detected by mass spectrometric investigation.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19793210504
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