ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Prediction of retention times
;
Gradient elution
;
Substituted quinolines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A chromatographic model able to predict, from experimental isocratic data, retention times of solutes under gradient conditions has been proposed previously. The prediction was shown to be totally independent of the chemical properties of both solutes and eluents. In order to further check the general validity of the theory, the model has now been applied to a nonhomologous set of compounds, namely a range of substituted quinolines (methyl-, hydroxy- and amino-) and several different stationary phases. Results show a dependence on the stationary phase and, to a lesser extent, on the chemical structure of the solutes. The possible sources of errors are discussed. The generality of the method holds, within acceptable limits, if predictions concern the same type of stationary phase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02290398
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