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  • 1
    Online Resource
    Online Resource
    Interaction of Nanomaterials With Living Cells (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Nanobiotechnology. ; Nanotechnology. ; Drug delivery systems. ; Regenerative medicine. ; Biomaterials. ; Cells. ; Nanobiotechnology. ; Nanotechnology. ; Drug Delivery. ; Regenerative Medicine and Tissue Engineering. ; Biomaterials-Cells.
    Description / Table of Contents: Chapter 1. Role of synthetic and natural biomaterials in modulating the autoimmune response -- Chapter 2. Nanotechnology-based biosensors in medicine -- Chapter 3. Materials from natural resources for the application of bone tissue engineering -- Chapter 4. Hydroxyapatite is a next-generation theranostic probe for tissue engineering and biomedical application -- Chapter 5. Green synthesis of metallic nanoparticles and various biomedical applications -- Chapter 6. Functionalized carbon nanotube for various disease treatment -- Chapter 7. Nanotechnology: Changing the world of animal health and veterinary medicine -- Chapter 8. Bioinspired materials inherited with antimicrobial properties for tissue engineering -- Chapter 9. 3D and 4D bioprinting technology for tissue engineering applications -- Chapter 10. Hemocompatibility of differently modified polymeric nanofibers: Current progress in the biomedical industry -- Chapter 11. Polyurethane nanofibers fabricated by electrospinning as drug carriers systems for the treatment of cancer -- Chapter 12. Recent trends in the application of materials for cancer therapy and diagnosis -- Chapter 13. Application of bioactive compounds and biomaterials in promoting cell differentiation, proliferation, and regenerating tissue -- Chapter 14. Materials for gene delivery systems -- Chapter 15. Natural hydrogels as wound dressing for skin wound healing applications -- Chapter 16. Nanomaterial applications in cancer therapy and diagnosis -- Chapter 17. Nanocellulose as a sustainable nanomaterial for films and coating layers via spray-coating and applications -- Chapter 18. Nanoparticles-based drug delivery system for beginners -- Chapter 19. Osteoarthritis: Novel insights in treatment -- Chapter 20. Promoting the Bio-potency of Bioactive Compounds through Nanoencapsulation -- Chapter 21. Review on green synthesis, modification, characterization, properties, and applications of palladium nanoparticles in biomedical applications -- Chapter 22. Innovative nanomaterials with profound antibacterial action applied in biomedical sciences -- Chapter 23. Musculoskeletal pains and its common diseases: Novel insights in treatments using biomaterials -- Chapter 24. Electrospun Cellulose and Derivatives-Based Nanofibers Loaded with Bioactive Agents for Wound Dressing Applications -- Chapter 25. Co-Delivery of Anticancer Drugs Using Polymer-Based Nanomedicines for Lung and Prostate Cancer Therapy -- Chapter 26. Silver nanoparticles incorporated textile substrate for antimicrobial applications -- Chapter 27. Recent advancement of gelatin for tissue engineering applications -- Chapter 28. Biomedical applications of the fused filament fabrication (FFF) technology -- Chapter 29. Role of Stem cells in the Delivery of Essential Pharmaceuticals -- Chapter 30. Biomaterials in autoimmune diseases -- Chapter 31. Regulatory and ethical issues raised by the utilization of nanomaterials.
    Abstract: This book examines the interactions of nanomaterials with the biological system. The chapters of the book explore the natural and synthetic biomaterials that modulate immune responses for their applications in drug delivery and tissue engineering. Further, the book discusses the implications of the physiochemical properties of nanoparticles and their microenvironment on their interactions with biological systems. The chapters also present the recognitive capabilities of biomaterials for the development of novel strategies for the detection and treatment of autoimmune disorders. The book also introduces nanotechnology platforms for drug delivery and highlights current and emerging nanotechnologies that could enable novel classes of therapeutics. Towards the end, the book reviews the efficiency of drug-loaded nanoparticles in modulating the functioning of the biological milieu for improved disease treatment. Lastly, the book outlines the ethical issues regarding the use of nanoparticles for in vitro and in vivo applications. Given its scope, it is a valuable resource for graduate students and researchers interested in understanding the biomedical applications of nanoparticles and their interactions with the biological milieu.
    Type of Medium: Online Resource
    Pages: XXIII, 924 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819921195
    URL: https://doi.org/10.1007/978-981-99-2119-5
    DOI: 10.1007/978-981-99-2119-5
    DDC: 620.5
    Language: English
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  • 2
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    Phosphorylation dynamics of eukaryotic initiation factor 4E binding protein 1 (4E-BP1) is discordant with its potential to interact with eukaryotic initiation factor 4E (eIF4E) (2014)
    Elsevier
    Details
    Publication Date: 2014-10-01
    Print ISSN: 0898-6568
    Electronic ISSN: 1873-3913
    Topics: Biology , Medicine
    Published by Elsevier
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  • 3
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    Strategies to Use Nanofiber Scaffolds as Enzyme-Based Biocatalysts in Tissue Engineering Applications (2021)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2021-04-22
    Description: Nanofibers are considered versatile materials with remarkable potential in tissue engineering and regeneration. In addition to their extracellular matrix-mimicking properties, nanofibers can be functionalized with specific moieties (e.g., antimicrobial nanoparticles, ceramics, bioactive proteins, etc.) to improve their overall performance. A novel approach in this regard is the use of enzymes immobilized onto nanofibers to impart biocatalytic activity. These nanofibers are capable of carrying out the catalysis of various biological processes that are essential in the healing process of tissue. In this review, we emphasize the use of biocatalytic nanofibers in various tissue regeneration applications. Biocatalytic nanofibers can be used for wound edge or scar matrix digestion, which reduces the hindrance for cell migration and proliferation, hence displaying applications in fast tissue repair, e.g., spinal cord injury. These nanofibers have potential applications in bone regeneration, mediating osteogenic differentiation, biomineralization, and matrix formation through direct enzyme activity. Moreover, enzymes can be used to undertake efficient crosslinking and fabrication of nanofibers with better physicochemical properties and tissue regeneration potential.
    Electronic ISSN: 2073-4344
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 4
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    Rapamycin inhibition of baculovirus recombinant (BVr) ribosomal protein S6 kinase (S6K1) is mediated by an event other than phosphorylation (2012)
    BioMed Central
    Details
    Publication Date: 2012-03-01
    Description: Background Ribosomal protein S6 kinase 1(S6K1) is an evolutionary conserved kinase that is activated in response to growth factors and viral stimuli to influence cellular growth and proliferation. This downstream effector of target of rapamycin (TOR) signaling cascade is known to be directly activated by TOR- kinase mediated hydrophobic motif (HM) phosphorylation at Threonine 412 (T412). Selective loss of this phosphorylation by inactivation of TOR kinase or activation/recruitment of a phosphatase has accordingly been implicated in mediating inhibition by rapamycin. Findings We present evidence that baculovirus driven expression of S6K1 in insect cells (Sf9) fails to activate the enzyme and instead renders it modestly active representing 4-6 folds less activity than its fully active mammalian counterpart. Contrary to the contention that viral infection activates TOR signaling pathway, we report that BVr enzyme fails to exhibit putative TOR dependent phosphorylation at the HM and the resultant phosphorylation at the activation loop (AL) of the enzyme, correlating with the level of activity observed. Surprisingly, the BVr enzyme continued to exhibit sensitivity to rapamycin that remained unaffected by mutations compromised for TOR phosphorylation (T412A) or deletions compromised for TOR binding (ΔNH 2-46/ΔCT104). Conclusions These data together with the ability of the BVr enzyme to resist inactivation by phosphatases indicate that inhibition by rapamycin is not mediated by any phosphorylation event in general and TOR dependent phosphorylation in particular.
    Electronic ISSN: 1478-811X
    Topics: Biology , Medicine
    Published by BioMed Central
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