Publication Date:
2011-07-20
Description:
Protein homeostasis within the endoplasmic reticulum (ER) is essential for cell viability, and its misregulation is implicated in a growing number of diseases, including Alzheimer's disease, diabetes, and cancer (1–3). Consequently, the pharmacological manipulation of this pathway is of broad scientific and clinical interest. A variety of drugs have been used to model specific types of stresses that impact protein folding in the ER. One of the most widely used is tunicamycin, a mixture of homologous compounds originally isolated from bacteria and found to have antibiotic and antiviral properties (4). Tunicamycin prevents the first committed step of N-linked glycosylation of...
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
Permalink