Publication Date:
2019-07-13
Description:
Three-dimensional/3-D organotypic models of human intestinal epithelium mimic the differentiated form and function of parental tissues often not exhibited by 2-D monolayers and respond to Salmonella in ways that reflect in vivo infections. To further enhance the physiological relevance of 3-D models to more closely approximate in vivo intestinal microenvironments during infection, we developed and validated a novel 3-D intestinal co-culture model containing multiple epithelial cell types and phagocytic macrophages, and applied to study enteric infection by different Salmonella pathovars.
Keywords:
Life Sciences (General)
Type:
JSC-CN-39067
,
ASM/ASV Conference on Interplay of Viral and Bacterial Pathogens 2017; May 01, 2017 - May 04, 2017; Bethesda, MD; United States
Format:
application/pdf
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