Publikationsdatum:
2018-06-14
Beschreibung:
A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro . These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.
Schlagwort(e):
medicinal chemistry, organic chemistry, synthetic chemistry
Digitale ISSN:
2054-5703
Thema:
Allgemeine Naturwissenschaft
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