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  • 1
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    Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-07-21
    Description: When rodents are infected with the nematode Nippostrongylus brasiliensis, large numbers of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil production in vivo and that IgE and eosinophil production are regulated by different cytokines produced by the TH2 subset of CD4-expressing T cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coffman, R L -- Seymour, B W -- Hudak, S -- Jackson, J -- Rennick, D -- New York, N.Y. -- Science. 1989 Jul 21;245(4915):308-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉DNAX Research Institute, Palo Alto, CA 94304.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2787531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal/*immunology ; Eosinophilia/etiology/*immunology ; Immunoglobulin E/immunology ; Interleukin-4 ; Interleukin-5 ; Interleukins/*immunology ; Mice ; Mice, Inbred BALB C ; Nematode Infections/*complications/immunology ; Nippostrongylus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Microclimates mitigate against hot temperatures in dryland ecosystems: termite mounds as an example (2016)
    Wiley
    In: Ecosphere
    Details
    Publication Date: 2016-11-12
    Description: Termite mounds have recently been shown to protect against drought by providing refuges for plants and foci for revegetation, but whether mounds modulate temperature remains untested. Organisms tend to experience climate at finer scales than those captured by models predicting how distributions alter with global change, so microclimates represent important “climate refuges.” Using data we collected from African savanna sites, generalized linear mixed-effects models and linear quantile regression analysis confirm for the first time that the woody species associated with large termite mounds establish microclimates that are significantly cooler than surrounding savannas, a cooling effect that is even greater at warmer extremes. As air temperatures approached 40°C, a cooling effect of up to 4°C occurred, representing a doubling from that observed at 34°C. African savannas encompass 10 million km 2 , and much of this harbors evenly dispersed termitaria. The temperature-modulating effect of mounds facilitates agricultural and conservation decision-making as global change begins to impact the integrity of both human well-being and ecological processes.
    Electronic ISSN: 2150-8925
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Wiley on behalf of The Ecological Society of America (ESA).
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