Publication Date:
2009-01-03
Description:
Most pathogens require a relatively long period of development in their mosquito vector before they can be transmitted to a new human host; hence, only older insects are of epidemiological importance. The successful transfer of a life-shortening strain of the inherited bacterial symbiont, Wolbachia, into the major mosquito vector of dengue, Aedes aegypti, halved adult life span under laboratory conditions. The association is stable, and the Wolbachia strain is maternally inherited at high frequency. It is capable of inducing complete cytoplasmic incompatibility, which should facilitate its invasion into natural field populations and its persistence over time. Our data suggest that targeting mosquito age with inherited Wolbachia infections may be a viable strategy to reduce the transmission of pathogens such as dengue viruses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McMeniman, Conor J -- Lane, Roxanna V -- Cass, Bodil N -- Fong, Amy W C -- Sidhu, Manpreet -- Wang, Yu-Feng -- O'Neill, Scott L -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):141-4. doi: 10.1126/science.1165326.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Integrative Biology, University of Queensland, Brisbane 4072, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119237" target="_blank"〉PubMed〈/a〉
Keywords:
Aedes/genetics/*microbiology/physiology/virology
;
Animals
;
Blood
;
Dengue/transmission
;
Dengue Virus/growth & development
;
Female
;
Humans
;
Insect Vectors/genetics/*microbiology/physiology/virology
;
Longevity
;
Male
;
Reproduction
;
Symbiosis
;
Temperature
;
Wolbachia/pathogenicity/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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