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  • 1
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    Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-12-10
    Description: The concept of germ layers has been one of the foremost organizing principles in developmental biology, classification, systematics and evolution for 150 years (refs 1 - 3). Of the three germ layers, the mesoderm is found in bilaterian animals but is absent in species in the phyla Cnidaria and Ctenophora, which has been taken as evidence that the mesoderm was the final germ layer to evolve. The origin of the ectoderm and endoderm germ layers, however, remains unclear, with models supporting the antecedence of each as well as a simultaneous origin. Here we determine the temporal and spatial components of gene expression spanning embryonic development for all Caenorhabditis elegans genes and use it to determine the evolutionary ages of the germ layers. The gene expression program of the mesoderm is induced after those of the ectoderm and endoderm, thus making it the last germ layer both to evolve and to develop. Strikingly, the C. elegans endoderm and ectoderm expression programs do not co-induce; rather the endoderm activates earlier, and this is also observed in the expression of endoderm orthologues during the embryology of the frog Xenopus tropicalis, the sea anemone Nematostella vectensis and the sponge Amphimedon queenslandica. Querying the phylogenetic ages of specifically expressed genes reveals that the endoderm comprises older genes. Taken together, we propose that the endoderm program dates back to the origin of multicellularity, whereas the ectoderm originated as a secondary germ layer freed from ancestral feeding functions.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359913/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359913/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hashimshony, Tamar -- Feder, Martin -- Levin, Michal -- Hall, Brian K -- Yanai, Itai -- 310927/European Research Council/International -- England -- Nature. 2015 Mar 12;519(7542):219-22. doi: 10.1038/nature13996. Epub 2014 Dec 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel. ; Department of Biology, Dalhousie University, Halifax, Nova Scotia B3H 4JI, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25487147" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Caenorhabditis elegans/cytology/*embryology/*genetics ; Cell Lineage ; Eating ; Ectoderm/cytology/embryology/metabolism ; Endoderm/cytology/embryology/*metabolism ; *Evolution, Molecular ; Gene Expression Profiling ; Gene Expression Regulation, Developmental/*genetics ; Mesoderm/cytology/embryology/metabolism ; Models, Biological ; Porifera/cytology/embryology/genetics ; Sea Anemones/cytology/embryology/genetics ; *Spatio-Temporal Analysis ; Time Factors ; Transcriptome/*genetics ; Xenopus/embryology/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistochemical identification of a vacuolar proton pump (V-ATPase) in bone-resorbing cells of an advanced teleost species, Oreochromis niloticus (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 55 (1999), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Poly-and monoclonal antibodies, raised against mammalian membrane-bound proton pump (V-ATPase) were applied to the bone-resorbing cells of Oreochromis niloticus to clarify if osteoclasts of an advanced teleost species display V-ATPase, a key enzyme in the process of bone resorption. All antibodies labelled cells at known sites of bone resorption, the endosteal bone surfaces surrounding the tooth anlagen. The best results were achieved with a monoclonal antibody (E11). Although the majority of labelled cells were flat and mononucleated, the occurrence of V-ATPase in these cells indicates that they function as active bone-resorbing cells. The monoclonal antibody E11 was also applied successfully to monocytes, cells that are believed to be related most closely to osteoclasts. The assignment of V-ATPase to boneresorbing cells of O. niloticus was confirmed by application of the additional osteoclast markers, tartrate-resistant acid phosphatase (TRAP) and tartrate-resistant ATPase (TraATPase). Co-expression of V-ATPase, TRAP and TraATPase in fish osteoclasts is demonstrated for the first time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1999.tb02074.x
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  • 3
    Electronic Resource
    Electronic Resource
    Bone resorption and bone remodelling in juvenile carp, Cyprinus carpio L. (2000)
    Oxford, UK : Blackwell Science, Ltd
    Journal of applied ichthyology 16 (2000), S. 0 
    Details
    ISSN: 1439-0426
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The present study considers the important role of bone resorption for bone growth in general, and aims to clarify if and how bone resorption contributes to the skeletal development of carp, Cyprinus carpio L., a teleost species with ‘normal’ osteocyte-containing (cellular) bone. To ensure the identification of osteoclasts and sites of bone resorption independently from the morphology of the bony cells, bones were studied by histological procedures, and by demonstration of the enzymes which serve as osteoclast markers, viz. tartrate resistant acid phosphatase (TRAP), ATPase and a vacuolar proton pump. Two types of bone-resorbing cells were observed in juvenile carp: (1) multinucleated giant cells displaying morphological and biochemical attributes which are known from mammalian osteoclasts; and (b) flat cells which lack a visible ruffled border and for which identification requires the performance of enzyme histochemical procedures. Bone resorption performed by osteoclasts mainly occurs at endosteal bone surfaces. To a lesser extent, bone resorption also takes place at periosteal bone surfaces, but without an apparent connection to bone growth. The latter observation, and the occurrence of bone remodelling, suggest that the endoskeleton of juvenile carp might be involved in mineral metabolism. Morphological differences and biochemical similarities to bone resorption in teleosts with acellular bone are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0426.2000.00233.x
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  • 4
    Electronic Resource
    Electronic Resource
    The origin of cartilage and bone from common stem cells (1970)
    Springer
    Calcified tissue international 4 (1970), S. 147-147 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02152399
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  • 5
    Electronic Resource
    Electronic Resource
    The relationship between migration and chondrogenic potential of trunk neural crest cells in Ambystoma mexicanum (1995)
    Springer
    Development genes and evolution 204 (1995), S. 477-483 
    Details
    ISSN: 1432-041X
    Keywords: Axolotl ; Neural crest ; Ambystoma mexicanum ; Cell migration ; Chondrogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Based on results of transplantation experiments, it has long been believed that trunk neural crest cells are incapable of chondrogenesis. When pigmented trunk neural crest cells of Ambystoma mexicanum are transplanted to cranial levels of albino (a/a) embryos, the graft cells ultimately produce ectopic fins, but are incapable of following the chondrogenic cranial neural crest pathways. Therefore, heterotopic transplantation does not expose these cells to the same environment experienced by cranial neural crest cells, and is neither an adequate nor a sufficient test of chondrogenic potential. However, in vitro culture of trunk neural crest cells with pharyngeal endoderm does provide a direct test of chondrogenic ability. That cartilage does not form under these conditions demonstrates conclusively that trunk neural crest cells possess no chondrogenic potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00360855
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  • 6
    Electronic Resource
    Electronic Resource
    Morphological integration in the cranium during anuran metamorphosis (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 872-875 
    Details
    ISSN: 1420-9071
    Keywords: Morphological integration ; skull ; Anura ; thyroid hormone ; metamorphosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We examined the role of thyroid hormone in mediating morphological integration between cranial cartilage and bone during anuran metamorphosis. Exogenous T3 applied to premetamorphic tadpoles (Bombina orientalis) via intracranial implants of plastic micropellets precociously induced typical metamorphic changes in both tissues, but also dissociated the relative timing of developmental events between them. Morphological integration between the two primary cranial tissues is achieved in part by each tissue responding independently to endocrine factors and does not reflect a tight developmental coupling between them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954061
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  • 7
    Electronic Resource
    Electronic Resource
    Analysis of lactate/malic dehydrogenase ratios as a technique to distinguish between progenitor cells of cartilage and bone (1976)
    Springer
    Calcified tissue international 22 (1976), S. 314-317 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02064087
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  • 8
    Electronic Resource
    Electronic Resource
    Differentiation of cartilage and bone from common germinal cells (1971)
    Springer
    Calcified tissue international 8 (1971), S. 276-286 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Cartilage ; Differentiation ; Collagen ; β-aminopropionitrile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé L'injection d'embryons de poulet, incubés pendant neuf jours, avec du β-aminopropionitrile (BAPN), à des doses supérieures à 0,312 mg par embryon, empêche la formation de cartilage, normalement présent au niveau des os de membrane à partir du llème jour de l'inculation. L'hitsogenese de cette inhibition est décrite. BAPN augmente la propertion de collagène et diminue la synthèse des mucopolysaccharides acides, contenant de l'hesoxamine, au niveau des os de membrane. Le rapport entre les chainons tranversaux du collagène, sa solubilité, la synthèse des mucopolysaccharides acides et la stimulation mécanique (le facteur extrinsèque déclenchant la chondrogenèse dans le système) est discuté sous l'angle de la formation cartilagineuse sur les os de membrane, à partir de cellules souches.
    Abstract: Zusammenfassung Wird β-Aminopropionitrol (BAPN) in Dosen von über 0,312 mg/Embryo in 9 Tage inkubierte Hühnerembryonen injiziert, so wird die Bildung des normalerweise vom 11. Inkubationstag an auf dem Deckknochen vorliegenden Knorpels verhindert. Die Histogenese dieser Hemmung wird beschrieben. BAPN erhöhte den Anteil des löslichen Kollagens, ohne die Synthese des Totalkollagens zu verändern; es verminderte die Synthese der hexosaminhaltigen sauren Mucopolysaccharide innerhalb der Deckknochen. Die Diskussion betrifft die Beziehung zwischen der Quervernetzung des Kollagens, der Kollagenlöslichkeit, der Synthese von sauren Mucopolysacchariden und der mechanischen Stimulation (wobei der Extrinsicfaktor die Chondrogenese in diesem System auslöst) bei der Knorpelbildung aus den bipotentialen Keimzellen der Deckknochen.
    Notes: Abstract Injection into chick embryos incubated for nine days, of β-aminopropionitrile (BAPN) at doses above 0.312 mg/embryo prevented the formation of the cartilage normally present on the membrane bones from the eleventh day of incubation onwards. The histogenesis of this inhibition is described. BAPN increased the proportion of soluble collagen without altering total collagen synthesis and decreased the synthesis of hexosamine-containing acid mucopolysaccharides within the membrane bones. The relationship between cross-linking of collagen, collagen solubility, synthesis of acid mucopolysaccharides and mechanical stimulation (the extrinsic factor initiating chondrogenesis in this system) in the formation of cartilage from bipotential germinal cells on the membrane bones is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010147
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  • 9
    Electronic Resource
    Electronic Resource
    Histochemical aspects of the differentiation of adventitious cartilage on the membrane bones of the embryo chick (1968)
    Springer
    Histochemistry and cell biology 16 (1968), S. 206-219 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The histochemistry of the adventitious cartilage of the chick has been studied and compared with both primary cartilage and the bone on which the adventitious cartilage develops. The distribution of DNA, RNA, collagen, acid mucopolysaccharide, mucoprotein, glycogen, lipid, alkaline phosphatase and inorganic phosphate has been studied. Adventitious cartilage was found to have the histochemistry of primary hypertrophic cartilage and to calcify. The appearance of lipid and alkaline phosphatase activity coincided with the onset of calcification. The proliferating osteogenic and chondrogenic cells of the chick embryo have been classified and compared histochemically. Collagen synthesis was found to be high in the osteogenic cells and acid mucopolysaccharide and mucoprotein synthesis high in the chondrogenic cells. It has been postulated that the morphogenetic switch from osteogenesis to adventitious chondrogenesis most probably involves a change in the rate of collagen and acid mucopolysaccharide synthesis by the germinal cells of the membrane bones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307849
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of temperature on morphological landmarks critical to growth and survival in larval Atlantic cod (Gadus morhua) (1996)
    Springer
    Marine biology 124 (1996), S. 593-606 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The morphology and function of structures important to energy acquisition were studied from spawning to the stage of transformation of larva to pelagic juvenile in Atlantic cod, Gadus morhua L., from December 1991 to July 1992. Fertilized eggs produced by adult fish from two genetically discrete populations (Newfoundland and Scotian Shelf) were raised under similar conditions in the laboratory at temperatures of 5 and 10°C. Subsamples of larvae were removed from cultures daily for 10 d, and then less frequently, and fixed for light microscopy and scanning electron microscopy. Nine functional morphological “landmarks” important to feeding, respiration and locomotion were chosen from observation of 280 ind. These landmarks defined 12 major developmental stages, from hatching to the pelagic juvenile stage. One of the feeding landmarks, intestinal stage, varied as a function of age and size and the variance in development was higher at 10°C than at 5°C; Newfoundland larvae developed more complex intestines than did Scotian Shelf larvae. In addition, Newfoundland larvae had significantly higher growth rates than those of Scotian Shelf larvae. Despite the higher growth rates and greater structural complexity of the intestine in Newfoundland larvae, the rate of yolk utilization was not significantly different between Newfoundland and Scotian Shelf larvae. Staging of respiratory landmarks showed that the gill arches were probably used preferentially in feeding while respiration was cutaneous. The gills, operculum and gill rakers developed late in larval life and accompanied the transition from cutaneous to branchial respiration. In the yolk-sac period, development of feeding and respiratory structures may be largely genetically controlled. During exogenous feeding, extrinsic factors also become important, as shown by the size and age-independent variation in intestinal development of larval cod raised at different temperatures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00351041
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