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  • 1
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    Retinal stem cells in the adult mammalian eye (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-17
    Description: The mature mammalian retina is thought to lack regenerative capacity. Here, we report the identification of a stem cell in the adult mouse eye, which represents a possible substrate for retinal regeneration. Single pigmented ciliary margin cells clonally proliferate in vitro to form sphere colonies of cells that can differentiate into retinal-specific cell types, including rod photoreceptors, bipolar neurons, and Muller glia. Adult retinal stem cells are localized to the pigmented ciliary margin and not to the central and peripheral retinal pigmented epithelium, indicating that these cells may be homologous to those found in the eye germinal zone of other nonmammalian vertebrates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tropepe, V -- Coles, B L -- Chiasson, B J -- Horsford, D J -- Elia, A J -- McInnes, R R -- van der Kooy, D -- New York, N.Y. -- Science. 2000 Mar 17;287(5460):2032-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Cell Biology, University of Toronto, Medical Sciences Building 1105, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10720333" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Count ; Cell Differentiation ; Cell Division ; Cell Lineage ; Cell Size ; Cell Survival ; Cells, Cultured ; Clone Cells ; Colony-Forming Units Assay ; Fibroblast Growth Factor 2/pharmacology ; Homeodomain Proteins/biosynthesis ; Intermediate Filament Proteins/biosynthesis ; Mice ; *Nerve Tissue Proteins ; Nestin ; Neuroglia/cytology/metabolism ; Neurons/cytology/metabolism ; Pigment Epithelium of Eye/cytology/embryology ; Retina/*cytology/embryology/metabolism ; Retinal Rod Photoreceptor Cells/cytology/metabolism ; Stem Cells/*cytology/metabolism ; Transcription Factors/biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    The application of antisense oligonucleotide technology to the brain: Some pitfalls (1994)
    Springer
    Cellular and molecular neurobiology 14 (1994), S. 507-521 
    Details
    ISSN: 1573-6830
    Keywords: c-fos ; egr-1 ; antisense oligodeoxynucleotides (ODNs) ; amygdala kindling ; immediate-early genes ; ODN-induced toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Amphetamine-induced c-fos andegr-1 expression in the striatum was used as a model in which to study the effects of antisense oligodeoxynucleotides (ODNs) directed at c-fos. Using direct infusions of ODNs into the striata of animals we have demonstrated that c-fos antisense ODNs retain most of their biological activity with 2- or 3-base substitutions. The c-fos antisense and mismatch ODNs attenuated Fos immunoreactivity but had little effect on Egr-1 immunoreactivity. 2. In another group of studies examining the role of c-fos in amygdala kindling, we have demonstrated that ODNs cause neurotoxic damage following repeated daily infusions into the amygdala. The damage observed was greatly diminished when the time interval between infusions was extended.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088834
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    Paper (German National Licenses)
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  • 3
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    The application of antisense oligonucleotide technology to the brain: Some pitfalls (1994)
    Springer
    Details
    Publication Date: 1994-10-01
    Print ISSN: 0272-4340
    Electronic ISSN: 1573-6830
    Topics: Biology
    Published by Springer
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