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  • 1
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    Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes (2016)
    Springer Nature
    Details
    Publication Date: 2016-06-17
    Description: Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes Cell Death and Disease 7, e2263 (June 2016). doi:10.1038/cddis.2016.163 Authors: L Montorsi, S Parenti, L Losi, F Ferrarini, C Gemelli, A Rossi, G Manco, S Ferrari, B Calabretta, E Tagliafico, T Zanocco-Marani & A Grande
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-08-02
    Description: To determine the role of the BCR-ABL gene in the proliferation of blast cells of patients with chronic myelogenous leukemia, leukemia blast cells were exposed to synthetic 18-mer oligodeoxynucleotides complementary to two identified BCR-ABL junctions. Leukemia colony formation was suppressed, whereas granulocyte-macrophage colony formation from normal marrow progenitors was unaffected. When equal proportions of normal marrow progenitors and blast cells were mixed, exposed to the oligodeoxynucleotides, and assayed for residual colony formation, the majority of residual cells were normal. These findings demonstrate the requirement for a functional BCR-ABL gene in maintaining the leukemic phenotype and the feasibility of gene-targeted selective killing of neoplastic cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szczylik, C -- Skorski, T -- Nicolaides, N C -- Manzella, L -- Malaguarnera, L -- Venturelli, D -- Gewirtz, A M -- Calabretta, B -- CA09644/CA/NCI NIH HHS/ -- CA36896/CA/NCI NIH HHS/ -- CA46782/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 Aug 2;253(5019):562-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Temple University Medical School, Philadelphia, PA 19140.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1857987" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Blast Crisis/genetics/pathology ; Cell Division/drug effects ; Exons ; Fusion Proteins, bcr-abl/*genetics ; Gene Expression/drug effects ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/*pathology ; Molecular Sequence Data ; Monocytes/cytology/drug effects ; Oligonucleotides, Antisense/*pharmacology ; *Oncogenes ; RNA, Messenger/analysis/genetics ; Tumor Cells, Cultured/cytology/drug effects ; Tumor Stem Cell Assay ; beta 2-Microglobulin/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    G1/S transition in normal human T-lymphocytes requires the nuclear protein encoded by c-myb (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-07-14
    Description: Exposure of peripheral blood mononuclear cells (PBMC) to an 18-base c-myb antisense oligomer before mitogen or antigen stimulation resulted in almost complete inhibition of c-myb messenger RNA and protein synthesis and blockade of T lymphocyte proliferation. Expression of early and late activation markers, interleukin-2 receptor and transferrin receptor, respectively, by PBMC was unaffected by antisense oligomer exposure as was the expression of c-myc messenger RNA. In contrast, histone H3 messenger RNA levels and DNA content were selectively decreased. These results suggest that c-myb protein deprivation does not perturb T lymphocyte activation or early molecular events that may prepare the cell for subsequent proliferation. Rather, it appears to specifically block cells in late G1 or early S phase of the cell cycle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gewirtz, A M -- Anfossi, G -- Venturelli, D -- Valpreda, S -- Sims, R -- Calabretta, B -- CA01324/CA/NCI NIH HHS/ -- CA36896/CA/NCI NIH HHS/ -- CA46782/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1989 Jul 14;245(4914):180-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2665077" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; DNA/biosynthesis ; Fluorescent Antibody Technique ; Gene Expression Regulation ; Humans ; Image Processing, Computer-Assisted ; *Interphase ; *Lymphocyte Activation/drug effects ; Oligonucleotides/pharmacology ; Oligonucleotides, Antisense ; Proto-Oncogene Proteins/biosynthesis/*genetics/physiology ; Proto-Oncogene Proteins c-myb ; Proto-Oncogenes ; RNA, Messenger/biosynthesis/*genetics ; Receptors, Interleukin-2/biosynthesis ; Receptors, Transferrin/biosynthesis ; T-Lymphocytes/*cytology/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Lineage-specific requirement of c-abl function in normal hematopoiesis (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-09-08
    Description: Structural abnormalities of the c-abl proto-oncogene are found in hematopoietic cells of more than 90 percent of individuals with chronic myelogenous leukemia. Therefore c-abl may be important in normal as well as malignant hematopoiesis. Normal human hematopoietic progenitor cells were exposed to three different c-abl sense or antisense oligodeoxynucleotides, and the effects on myeloid and erythroid colony formation were examined. The c-abl antisense oligodeoxynucleotides inhibited myeloid, but not erythroid, colony formation. The c-abl sense oligodeoxynucleotides and bcr sense and antisense oligodeoxynucleotides were not inhibitory in this assay. These data show that c-abl is critical in normal myelopoiesis and may explain the relatively selective expansion of leukocytes in patients with chronic myelogenous leukemia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Caracciolo, D -- Valtieri, M -- Venturelli, D -- Peschle, C -- Gewirtz, A M -- Calabretta, B -- CA01324/CA/NCI NIH HHS/ -- CA36896/CA/NCI NIH HHS/ -- CA46782/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1989 Sep 8;245(4922):1107-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Istituto di Medicina ed Oncologia Sperimentale, Sezione di Ematologia, Torino, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2672339" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Cells/drug effects/metabolism/physiology ; Bone Marrow ; Cell Differentiation/drug effects ; Colony-Forming Units Assay ; Erythropoiesis/drug effects ; *Hematopoiesis/drug effects ; Hematopoietic Stem Cells/drug effects/metabolism/physiology ; Humans ; Oligonucleotides/pharmacology ; Oligonucleotides, Antisense ; Proto-Oncogene Proteins/biosynthesis ; *Proto-Oncogenes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    A c-myb antisense oligodeoxynucleotide inhibits normal human hematopoiesis in vitro (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-12-02
    Description: The nuclear protein encoded by the proto-oncogene c-myb has been hypothesized to play an important role in the process of hematopoiesis, but direct proof of this function has been lacking. To address this issue, normal human bone marrow mononuclear cells were exposed to c-myb sense and antisense synthetic oligodeoxynucleotides, and the effects on hematopoietic colony formation and maturation were examined. Exposure of these cells to c-myb antisense, oligodeoxynucleotides resulted in a decrease in both colony size and number, without apparent effect on the maturation of residual colony cells. Exposure to c-myb sense, or irrelevant antisense, oligonucleotides had no such effect. These results show that (i) c-myb plays a critical role in regulating normal human hematopoiesis and (ii) the combined use of antisense oligodeoxynucleotides and hematopoietic cell culture techniques will provide a powerful tool for studying the role of proteins encoded by proto-oncogenes, or other specific genes, in normal human hematopoiesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gewirtz, A M -- Calabretta, B -- CA 01324/CA/NCI NIH HHS/ -- CA 36896/CA/NCI NIH HHS/ -- CA 46782/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1988 Dec 2;242(4883):1303-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University School of Medicine, Philadelphia, PA 19140.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2461588" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Differentiation ; Cell Division ; Clone Cells ; *Hematopoiesis ; Humans ; In Vitro Techniques ; Nuclear Proteins/*physiology ; Oligodeoxyribonucleotides/chemical synthesis ; Peroxidase/genetics ; Proto-Oncogene Proteins/*physiology ; Proto-Oncogene Proteins c-myb ; Rna ; RNA, Antisense
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-06-10
    Description: The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase delta. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaskulski, D -- deRiel, J K -- Mercer, W E -- Calabretta, B -- Baserga, R -- CA 42866/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1988 Jun 10;240(4858):1544-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, Temple University Medical School, Philadelphia, PA 19140.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2897717" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantigens/*genetics ; Base Sequence ; Cell Division/drug effects ; Cells, Cultured ; Codon ; DNA Replication/*drug effects ; Kinetics ; Mice ; Mice, Inbred BALB C ; Mitosis/*drug effects ; Molecular Sequence Data ; Nuclear Proteins/*genetics ; Oligodeoxyribonucleotides/*pharmacology ; Proliferating Cell Nuclear Antigen
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
    Electronic Resource
    Electronic Resource
    Expression of c-myc and induction of DNA synthesis by platelet-poor plasma in human diploid fibroblasts
    Amsterdam : Elsevier
    Experimental Cell Research 174 (1988), S. 25-33 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(88)90138-3
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Cell cycle analysis of human peripheral blood T lymphocytes in long-term culture
    Amsterdam : Elsevier
    Experimental Cell Research 173 (1987), S. 70-79 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(87)90332-6
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  • 9
    Electronic Resource
    Electronic Resource
    TPA-induction of c-fos mRNA during the cell cycle of WI-38 human fibroblasts
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 147 (1987), S. 716-723 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(87)90989-2
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of interleukin-2 on the expression of cell cycle genes in human T lymphocytes
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 133 (1985), S. 410-416 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(85)90921-0
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