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  • 1
    Electronic Resource
    Electronic Resource
    Serum mineral changes in dithizone-induced diabetes before and after insulin treatment (1977)
    Springer
    European journal of nutrition 16 (1977), S. 22-26 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary In this study, diabetes was induced by intravenous injection of dithizone. In dithizonised diabetic animals, the levels of serum zinc, iron, and potassium were found to be higher than normal, while those of serum calcium and sodium were lower. Copper and magnesium levels were unchanged. After treatment with insulin, most of these serum levels approached the normal, except for serum potassium and magnesium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02021207
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of carbon-disulfide intoxication on the levels of serum copper and ceruloplasmin (1977)
    Springer
    European journal of nutrition 16 (1977), S. 77-80 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Under the effect of carbon-disulphide intoxication on the experimental animals, a significant decrease in serum copper and ceruloplasmin levels was observed. The decrease was aggravated with prolongation of carbon disulphide intoxication due to loss of appetite, formation of chelating compounds with carbon disulphide metabolites and increased loss of copper in urine. However, reinvestigated at 20 days after stoppage of dosage, most of these derangements started to be alleviated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02021482
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  • 3
    Electronic Resource
    Electronic Resource
    Serum mineral changes under the effect of carbon disulfide intoxication (1977)
    Springer
    European journal of nutrition 16 (1977), S. 153-157 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary Under the effect of carbon-disulfide intoxication on serum levels of zinc, iron, calcium, magnesium, potassium, and sodium of albino rats, five groups of rats were injected with daily doses of carbon disulfide over a period of 50 days. The extent of regression of the developed biochemical derangement was also studied. A significant decrease was observed in the levels of serum zinc, iron, calcium, and magnesium, while a slight elevation in the level of serum potassium. No definite correlation could be found between the level of serum sodium in control and carbon-disulfide intoxicated rats. By stoppage of dosage at 20 days, most of these derangements started to be normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024786
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  • 4
    Electronic Resource
    Electronic Resource
    Blood-reduced glutathione, pyruvic acid, citric acid, ceruloplasmin oxidase activity and certain mineral changes in diabetes mellitus before and after treatment (1978)
    Springer
    European journal of nutrition 17 (1978), S. 72-78 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary In maturity onset diabetes the blood levels of total blood keto acids in terms of pyruvic, serum citric, calcium are significantly higher than in normal adults, while there is a decrease in reduced-blood glutathione, serum zinc, potassium and sodium levels. There were no significant differences between diabetes and normal adults in the serum levels of copper, ceruloplasmin oxidase activity, iron and magnesium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02021113
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  • 5
    Electronic Resource
    Electronic Resource
    Evaluation of the effect of lead exposure on the liver in Egyptian lead tank welders (1980)
    Springer
    European journal of nutrition 19 (1980), S. 50-56 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary In a group of Egyptian lead tank welders who were exposed to lead fumes for periods to 22 years the changes in serum lipids and some of the liver function tests which may elucidate the effect of lead on the liver were investigated. The results revealed increased blood lead level associated with decreased blood haemoglobin and increased urinary excretion of delta amino levulinic acid. However, no clinical abnormalities were recorded in the exposed group of the present work. Thus the increase in serum triglycerides and B-lipoprotein together with the lowering of the phospholipid/cholesterol ratio which were found may indicate premature development of atherosclerosis. Indirect evidence of the beginning of liver fattening was also provided by the increase in serum GOT, GPT, LDH enzymes and decreased albumin/globulin ratio besides the changes in serum lipid values. It is concluded therefore that lead poisoning may have a vascular as well as hepato-toxic action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02021073
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of vitamin B12 on tetracycline-induced fatty liver (1980)
    Springer
    European journal of nutrition 19 (1980), S. 173-178 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary The effect of vitamin B12 on the metabolic alterations due to tetracycline toxicity was studied experimentally on laboratory animals. Treatment of Sprague-Dawley rats with 120 or 250 mg tetracycline (i.p.) per kg per day for two or three days caused an accumulation of lipids, mainly triglycerides in the liver of 75% of animals studied, while phospholipid level tend to decrease. These doses are approximately twice and four times the recommended maximum dose for man. In the present work no direct relationship was observed between dose of tetracycline and hepatic accumulation of triglyceride, although livers of rats treated with 250 mg tetracycline/kg appeared uniformly pale yellow. Elevated serum triglyceride was found predominantly in rats treated with 120 mg/kg, while there was no obvious difference between serum triglyceride of rats treated with 250 mg tetracycline and control rats, indicating a block in the release of hepatic triglycerides. Where protection by vitamin B12 was studied, the vitamin was given i.m. (50 μg/ animal) 3 hours before the injection of 120 mg tetracycline per kg. There was a good evidence that lipid abnormalities caused by tetracycline improved by vitamin B12. Thus both hepatic and serum total lipid and triglycerides were significantly lower than those of rats treated with tetracycline, although hepatic total cholesterol was significantly increased as in case of tetracycline only.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02018783
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  • 7
    Electronic Resource
    Electronic Resource
    The effect of ATP and certain trace elements on the induction of experimental diabetes (1977)
    Springer
    European journal of nutrition 16 (1977), S. 176-183 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary The intravenous injection of zinc chloride immediately before and fifteen minutes after alloxan or dithizone prevented the usual hyperglycaemia observed 24 hours after induction of diabetes. This is supported by histological examination which showed that the itslets of those animals which were injected with zinc were intact and their beta cells stained normally. The intravenous injection of manganese chloride prevented any marked rise of blood glucose, without protecting the islets. Chromium and cobalt chloride lowered the blood-glucose level to a certain extent. ATP given before alloxan could prevent any marked rise in blood sugar. ATP resulted also in a significant reduction in the fat and significant increase in the glycogen content of the liver in female rats examined on the 10th day after induction of alloxan diabetes. It is suggested that ATP as well as zinc, manganese, chromium, and cobalt ions seem to be essential for both insulin secretion as well as glucose utilization by various tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024790
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  • 8
    Electronic Resource
    Electronic Resource
    Biochemical changes under the effect of carbon tetrachloride intoxication (1977)
    Springer
    European journal of nutrition 16 (1977), S. 217-222 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary The present study deals with investigations on the general features of protein and iron metabolism under several conditions of chronic and acute liver damage induced by carbon tetrachloride. Data revealed a drop in the levels of serum total protein and albumin. The levels of alpha1, alpha2 and beta globulins were found to be increased. Gamma fraction was found to be proportionate with dosage accumulation and to varying extent. There were changes in haematocrit and haemoglobin values in all groups of chronic and acute carbon tetrachloride intoxicated rats. Also, there were no changes in reticulocyte count, plasma iron and total iron binding capacity levels in chronic intoxicated animals. However, in acute carbon tetrachloride plasma iron and total iron-binding capacity were significantly elevated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02023698
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of drugs affecting microsomal enzymes on serum protein pattern and fat content of the liver (1978)
    Springer
    European journal of nutrition 17 (1978), S. 180-187 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary The influence of phenobarbitone and propionyl-promazine given in ten repeated doses together with small doses of CCl4 on serum protein pattern and fat content of the liver was investigated in albino rats. The data revealed a marked increase of the fat content of the liver under the influence of CCl4. However, when phenobarbitone was administered together with CCl4 it resulted in a significant reduction in the fat content of the liver. Nevertheless, in comparison with the control experiments it was found that under the influence of phenobarbitone whether it was administered alone or together with CCl4, the fat content of the liver was significantly higher than that of the control. Concerning the changes in the total protein and its fractions, a state of hypoproteinemia and hypoalbuminemia was observed in rats with severe CCl4 intoxication. While the globulin fractions increased, the A/G ratio was therefore significantly decreased. However, when phenobarbitone was administered together with CCl4 there was no statistically significant difference in the percentage of the different protein fractions nor in the A/G ratio as compared with the control group. Propionyl-promazine when was administered alone or together with CCl4 has no effect on the fat content of the liver and serum protein pattern. It is concluded that under the present experimental conditions, the main protective effect of phenobarbitone seems to be due to an antagonistic action of phenobarbitone in CCl4 induced decomposition at the level of the endoplasmic reticulum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02020908
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  • 10
    Electronic Resource
    Electronic Resource
    Serum mineral changes due to exogenous ATP and certain trace elements in experimental diabetes (1979)
    Springer
    European journal of nutrition 18 (1979), S. 1-7 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Notes: Summary The intravenous injection of zinc or manganese chloride immediately before and 15 minutes after alloxan or dithizone prevented the usual hyperglycemia observed 24 hours after induction of diabetes. Injection of zinc chloride in alloxan diabetes led to normalization of sodium while zinc, copper, iron and magnesium remained high and calcium and potassium remained low as in alloxan. In case of dithizone diabetes, the administration of zinc salt led to an increase in serum zinc, magnesium and potassium and to a decrease in serum calcium while the sodium level returned to normal. Manganese plus alloxan led to a normalization of serum zinc, copper, potassium and sodium. In the case of dithizone plus manganese only magnesium was raised while the other elements were unchanged when compared to animals injected with dithizone only. Chromium and cobalt chloride lowered the blood glucose to a certain extent however it did not affect most of the elements. The same changes occurred in all elements as with alloxan or dithizone alone. Pretreatment with ATP led to a normalization of serum zinc, copper, magnesium, sodium and potassium, while in case of iron it remained high and calcium remained low as that found in alloxan diebetic rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02026530
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