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  • 1
    Electronic Resource
    Electronic Resource
    HPLC determination of glutathione and l-cysteine in pharmaceuticals after derivatization with ethacrynic acid
    Amsterdam : Elsevier
    Journal of Pharmaceutical and Biomedical Analysis 12 (1994), S. 91-98 
    Details
    ISSN: 0731-7085
    Keywords: Glutathione ; ethacrynic acid and its methyl ester ; l-cysteine ; liquid chromatography. ; pre-chromatographic derivatization
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0731-7085(94)80015-4
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  • 2
    Electronic Resource
    Electronic Resource
    HPLC analysis of imidazole antimycotic drugs in pharmaceutical formulations
    Amsterdam : Elsevier
    Journal of Pharmaceutical and Biomedical Analysis 10 (1992), S. 873-879 
    Details
    ISSN: 0731-7085
    Keywords: Reversed-phase chromatography (HPLC) ; imidazole antimycotic drugs ; pharmaceutical formulations. ; post-column photochemical reaction ; solid-phase extraction
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0731-7085(91)80094-P
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of glutathione in pharmaceuticals and cosmetics by HPLC with UV and fluorescence detection (1994)
    Springer
    Chromatographia 39 (1994), S. 23-28 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Glutathione ; Pharmaceuticals and cosmetics ; Pre-chromatographic derivatization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A selective HPLC determination of reduced glutathione (GSH) in pharmaceutical and cosmetic formulations is described based on prechromatographic derivatization with 4-(6-methylnaphthalen-2-yl)-4-oxo-2-buteneoic acid. The derivatization reaction is rapid under mild reaction conditions (10 min at ambient temperature and pH 7.5) and the excess reagent can be removed by liquid-liquid extraction. The thiol adducts were chromatographed on a C-8 column using 0.05 M triethylammonium phosphate (pH 4.0) — acetonitrile 68∶32 (v/v), as the mobile phase; UV and fluorescence detection (lem 450 nm, lexc 300 nm) were both used. The structure of the thiol adducts was confirmed by1H and13C NMR spectra using sodium methanethiolate as thiol nucleophile.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02320453
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  • 4
    Electronic Resource
    Electronic Resource
    HPLC determination of 18 β-glycyrrhetinic and glycyrrhizinic acids in toothpastes after solid phase extraction (1993)
    Springer
    Chromatographia 35 (1993), S. 167-172 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; 18 β-glycyrrhetinic acid ; Glycyrrhizinic acid ; Toothpastes ; Solid phase extraction (SPE)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary HPLC methods suitable for the selective and sensitive determination of 18 β-Glycyrrhetinic acid (GT) and Glycyrrhizinic acid (GZ) in toothpastes have been developed. The methods involve a preliminary quantitative solid phase extraction (C-18 sorbent) for sample clean-up and analyte concentration. Chromatographic separations were performed on reversed phase (C-8; C-18) columns using mixtures of methanol and phosphate buffers (pH 3.0) as the mobile phase under isocratic or gradient elution conditions. The method were applied successfully to the analysis of commercial toothpastes containing low levels (0.013–0.065%) of GT and GZ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02269697
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  • 5
    Electronic Resource
    Electronic Resource
    Analysis of basic hair dyes by HPLC with on-line post-column photochemical derivatisation (1994)
    Springer
    Chromatographia 39 (1994), S. 138-145 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Diode array detection ; Post-column photochemical derivatisation ; Hair dyes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A reversed phase liquid chromatographic method is proposed for the analysis of basic hair dyes (raw materials and colourant formulations). The performance of the method was enhanced by introducing post-column on-line photochemical derivatisation in combination with a Diode Array Detector. On-line photoderivatisation provided an effective way of selectively transforming the analytes to compounds with different spectral properties. For each analyte two characteristic UV-Visible spectra (photoreactor on and off) were obtained with the same mobile phase and this information in combination with the chromatographic data (k' at pH 3.0 and 4.5) enabled the unambiguous identification of both commonly used, approved, and banned basic hair dyes. Additionally, this approach was found useful to improve the method sensitivity, allowing the determination of analytes present in low concentration (0.03%) in complex commercial formulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274492
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  • 6
    Electronic Resource
    Electronic Resource
    Enantioselective separation of chiral arylcarboxylic acids on an immobilized human serum albumin chiral stationary phase (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 9 (1997), S. 178-183 
    Details
    ISSN: 0899-0042
    Keywords: chiral recognition mechanisms ; quantitative structure ; enantioselective retention relationships ; chiral chromatography ; enantioselective separations ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A series of 12 chiral arylcarboxylic acids were chromatographed on an immobilized human serum albumin chiral stationary phase (HSA-CSP). The effects of solute structure on chromatographic retentions and enantioselective separations were examined by linear regression analysis and the construction of quantitative structure-enantioselective retention relationships. Competitive displacement studies were also conducted using R-ibuprofen as the displacing agent. The results indicate that the enantioselective retention of the solutes takes place at the indole-benzodiazepine site (site II) on the HSA molecule and that chiral recognition is affected by the hydrophobicity and steric volume of the solutes. The displacement studies also identified a cooperative allosteric interaction induced by the binding of R-ibuprofen to site II. Chirality 9:178-183, 1997. © 1997 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    1,1′-[Ethenylidenebis(sulfonyl)]bis-benzene: A useful pre-chromatographic derivatization reagent for HPLC analysis of thiol drugs (1996)
    Springer
    Chromatographia 42 (1996), S. 515-520 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Thiol drugs ; Pre-chromatographic derivatization ; 1,1′-[ethenylidenebis(sulfonyl)]bis-benzene reagent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The use of 1,1′-[ethenylidenebis(sulfonyl)]bis-benzene as a pre-chromatographic reagent for LC analysis of thiol drugs is proposed. The reagent reacts rapidly (2 min) under mild conditions (pH 7.5, ambient) with thiol drugs and the resulting adducts can be chromatographed under reversed-phase conditions (C-18 column). Excess reagent can be removed from the reaction mixture by simple liquid-liquid extraction with chloroform. The HPLC method using UV detection was successfully applied to the analysis of reduced glutathione (GSH), N-acetylcysteine, N-2-mercaptopropionylglycine and captopril in their commercial formulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290285
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  • 8
    Electronic Resource
    Electronic Resource
    Analysis of semipermanent hair dyes by HPLC with on-line post-column photochemical derivatisation (1997)
    Springer
    Chromatographia 44 (1997), S. 431-437 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Photochemical derivatisation ; Semipermanent hair dyes ; Cosmetic formulations ; Stability study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The development of a selective and sensitive HPLC method for the determination of semipermanent hair colorants in cosmetic formulations is proposed. The separation and identification of N-hydroxyalkyl nitrophenylenediamines and nitroaminophenols were performed by HPLC with on-line, post-column, photochemical derivatisation, using a reversed phase, ion-pair system with 1,8-diaminooctane and heptansulfonate in the mobile phase. Two UV spectra (photoreactor on and off) were obtained for each analyte, adding information for confirming peak identity. Analyte-modified spectral properties were used to increase the method sensitivity. The proposed method was successfully applied to quality control and stability studies of cosmetic formulations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02466323
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  • 9
    Electronic Resource
    Electronic Resource
    HPLC analysis of basic organic compounds in a multi-component ion-interaction system: A mechanistic study (1998)
    Springer
    Chromatographia 47 (1998), S. 493-500 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Ion-interaction chromatography ; Basic organic compounds ; Diamine modifiers ; Retention mechanism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Reversed-phase HPLC separations of basic compounds have been optimized by use of mobile phases containing 1,8-diaminooctane (DAO) as amine modifier and heptanesulfonate as counter-ion. Such studies have demonstrated the high resolution and selectivity of this chromatographic system compared with mobile phases prepared with the more widely used primary amines. With the aim of clarifying the retention mechanism involved, three sets of compounds with different structures and properties were analyzed: sulfamidics and trimethoprim, aromatic diamines and aminophenols, and a standard mixture of lipophilic basic drugs. The conditions investigated were: diaminoalkane modifier concentration, diaminoalkane modifier alkyl-chain length, nature and concentration of the counter-ion, pH of the mobile phase, concentration of the organic modifer, and the nature of the stationary phase as characterized by percentage carbon loading. Analysis of chromatographic behavior as a function of the chromatographic conditions has enabled the proposal of a mechanism of retention of the three classes of compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02467485
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  • 10
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    Modulation of chromatographic performances of HSA-based HPLC column by reversible binding of lithocholic acid (2001)
    Springer
    Details
    Publication Date: 2001-05-01
    Print ISSN: 0009-5893
    Electronic ISSN: 1612-1112
    Topics: Chemistry and Pharmacology
    Published by Springer
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