Publication Date:
2013-11-15
Description:
L-asparaginase has been a major drug in the treatment of acute lymphoblastic leukemia (ALL) over the past decades, its efficacy has been demonstrated in a broad range of patient clinical profiles. However frequence and severity of toxicities, of which allergic reactions, have been a major drawback. L-asparaginase loaded inside homologous red cells, suspended in SAG-mannitol preservative solution, (GRASPA) is a new available formulation for administering L-asparaginase in combination with standard chemotherapy in different ALL populations, including frail patients older than 55years. Tolerability and efficacy of GRASPA in patients with ALL have been investigated in successive clinical trials (GRASPALL 2005-01 and GRASPALL/GRAALL-SA2-2008). The global toxicity of this new L-asparaginase formulation is decreased, in all age groups, with fewer hypersensitive reactions. A significant reduction of the coagulation disorders in patients
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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