ISSN:
1573-1111
Keywords:
Molecular anvil
;
high catalytic power
;
high specificity
;
spontaneous creation of a high energy state
;
felatively extruded distance
;
semi-inclusion phenomenon
;
slightly imperfect fitting
;
antibody
;
hapten
;
enzyme
;
enzyme activity
;
regulation of biological system
;
Boltzman factor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The concept of a molecular anvil model of an enzyme, assuming a rigid enzyme molecule, is introduced. Two distinct features of enzymes, high catalytic power and high specificity, are reasonably and consistently explained. The dynamic nature of molecular anvil action is stressed. The origin of the high catalytic power is the spontaneous creation of a high energy state at the anvil site. The origin of the high specificity is a high sensitivity of the maximum accessible potential energy to the relatively extruded distance of the molecular anvil. The flexible model is developed by assuming a flexible enzyme molecule. It is deduced from this flexible model that enzyme activity shows a maximum with a wide range of monotonous change of the configuration of the enzyme molecule. This is the origin of the general property of enzymes that enzyme activity shows a maximum with monotonous variation of environmental parameters such as pH, temperature, pressure or some times concentration of chemical substances. The induced fit theory of Koshland is reasonably explained. The relation and differences between individual theories of enzymes are discussed. The enzymological basis of the complex regulation of biological organisms is discussed. The inversion of the sign of control of effectors is predicted when environmental parameters are varied. This concept may be useful in designing artificial enzymes or high specificity catalysts.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00664113
Permalink
