ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
In order to develop bone substitute with osteogenic properties, a novel strategy ofgrafting cyclo-DfKRG peptides to enhance cells adhesion and osteointegration of hydroxyapatite(HA) implants was developed. Objectives of the study were (1) to evaluate the osteogenicproperties of HA implants grafted with RGD peptides and (2) to compare histomorphometry andmicro-computed tomography ((CT) with bone quantification. Pure HA grafted or not with cyclo-DfKRG peptides and autologous stromal cells was implanted in femoral condyle on 2 groups (2 and4 weeks) of 6 New Zealand rabbits. Measurements concerning bone reconstruction and materialstructure were obtained with a (CT and the results were compared to those obtained afterhistomorphometry. Finally, it appears that grafting cyclo-DfKRG on HA implants enhances nonsignificantlythe rate of bone formation, and a high correlation of the results was found comparinghistomorphometry and (CT analysis
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1169.pdf
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