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  • 1
    Electronic Resource
    Electronic Resource
    Cutaneous phototoxicity in photodynamic therapy: Clinical experience with and without histamine antagonists (1991)
    Springer
    Lasers in medical science 6 (1991), S. 179-182 
    Details
    ISSN: 1435-604X
    Keywords: Photodynamic therapy ; Skin photosensitivity ; Antihistamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract We have investigated the incidence of cutaneous phototoxicity in 47 patients who received photodynamic therapy between April 1988 and March 1990. Of these, 15 patients received antihistamines as part of a pilot study to evluate their photoprotective role. Patients were followed-up for a minimum of 8 weeks. One out of the fifteen who received antihistamines and 15 out of the 32 patients who did not (p〈0.005), developed cutaneous phototoxicity. On the basis of these results we have initiated a randomized double-blind trial to evaluate the role of antihistamines in haematoporphyrin derivative-induced cutaneous phototoxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032545
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  • 2
    Electronic Resource
    Electronic Resource
    Photosensitized patients and operating lights (1989)
    Springer
    Lasers in medical science 4 (1989), S. 269-274 
    Details
    ISSN: 1435-604X
    Keywords: Photochemotherapy ; Haematoporphyrin photoradiation ; Operative surgery ; Lighting ; Colonic neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Photosensitized patients who receive intra-operative photodynamic therapy are subjected to the intense brightness of operating lights. In order to investigate the potential phototoxic effects of this therapy, light energy densities were measured in non-photosensitized patients undergoing major abdominal surgery. The results show energy densities of 0.14 to 12.51 J cm−2 of polychromatic light for different operative fields. By a consideration of photon absorption numbers, these levels have a photodynamic equivalent of 0.34 to 30.06 J cm−2 of 630 nm light at the surface of tissue. If surgeons are unaware of the possible phototoxic effects of operating lights, some tissues could receive an unacceptably high energy density of polychromatic light. However, operating lights should not give significant phototoxic effects if the surgeon is aware and takes simple precautions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032458
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    Paper (German National Licenses)
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