ISSN:
1573-8221
Keywords:
brain ischemia
;
prostacyclin
;
arterial hypertension
;
hypoxia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Acute and chronic brain ischemia in dogs with rehabilitated hypertension is modeled by applying a tourniquet on the carotid artery. Occlusion of the coronary artery (60 and 120 min for 12 days) induces ischemic stress. Brain ischemia is accompanied by a decrease in plasma prostacyclin and the development of platelet hyperaggregation, which can produce thrombogenesis. The calcium antagonist nifedipine produces stress- and prostacyclin-protective effects by reducing platelet hyperaggregation and preventing thrombogenesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02446986
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