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  • 1
    Keywords: Pharmacology. ; Medicinal chemistry. ; Pharmaceutical chemistry. ; Biotechnology. ; Biochemical engineering. ; Pharmacology. ; Medicinal Chemistry. ; Pharmaceutics. ; Biotechnology. ; Bioprocess Engineering.
    Description / Table of Contents: Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.
    Abstract: The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
    Type of Medium: Online Resource
    Pages: XI, 207 p. 174 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811923203
    Series Statement: Progress in Drug Research, 76
    DDC: 615
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geochemistry. ; Mineralogy. ; Geology. ; Geochemistry. ; Mineralogy. ; Geology.
    Description / Table of Contents: Introduction -- Minerals with metallic and metallic-covalent bonds -- Minerals with metallic-covalent and ionic-covalent bond -- Minerals with principal ionic-covalent and covalent-ionic bond -- Minerals with principal covalent-ionic and ionic bond -- Carbon, its compounds (without carbonates) and related substances -- References.
    Abstract: This book represents new structural-chemical minerals of A.A. Godovikov which reflects the latest data on communication of the chemical composition with structure and properties of minerals, conditions of their formation, their paragenesis. The following features lay its basis: a) the numerous, often not considered earlier chemical signs on which chemical properties of minerals, conditions of their formation or paragenesis may depend; b) the determined consistent patterns of communication between chemical compounds structure and fundamental properties of the elements forming them; c) regularities of structure change and properties of minerals depending on physical and chemical parameters of formation or environment systems. This systematiс considers real associations, differences in physical and chemical parameters at which minerals are forming and existing. In this systematic sometimes the preference is given to the last signs because all natural associations aren't casual in an arrangement of minerals, so they formed as a result of difficult and longtime selection. The properties of minerals are coordinated with their structure, formation conditions. The transition conditions from one taxon to another both at one level and at its deepenings are accurately formulated. The primary type of a chemical bond was accepted as leading sign of five highest taxons. The lowest taxons were allocated on: a) the mineral belongings to izodesmichesky or anizodesmichesky connections; b) the type of anion, cation; c) the coordination number of an anionoobrazovatel; d) the size of CX; e) the type of the structure. The signs which are in the basis for systematization give the chance to find the place for new mineral types in the tables, to change the place of mineral in connection with specification of its formula or structure. They also allow to distinguish new taxons for the new mineral types representing chemical compounds, earlier not known in nature. Thus this systematic is not a stiffened representation but the developing system.
    Type of Medium: Online Resource
    Pages: XII, 313 p. 1 illus. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783319728773
    DDC: 551.9
    Language: English
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  • 3
    Call number: 9783030335663 (e-book)
    Description / Table of Contents: This book presents current knowledge on chemistry and physics of Arctic atmosphere. Special attention is given to studies of the Arctic haze phenomenon, Arctic tropospheric clouds, Arctic fog, polar stratospheric and mesospheric clouds, atmospheric dynamics, thermodynamics and radiative transfer as related to the polar environment. The atmosphere-cryosphere feedbacks and atmospheric remote sensing techniques are presented in detail. The problems of climate change in the Arctic are also addressed.
    Type of Medium: 12
    Pages: 1 Online-Ressource (723 Seiten) , Illustrationen
    ISBN: 9783030335663 (e-book)
    Series Statement: Springer Polar Sciences
    Language: English
    Note: Contents 1 Dynamical Processes in the Arctic Atmosphere / Marius O. Jonassen, Dmitry Chechin, Alexey Karpechko,Christof Lüpkes, Thomas Spengler, Annick Tepstra, Timo Vihma,and Xiangdong Zhang 2 Thermodynamics of the Arctic Atmosphere / Claudio Tomasi, Boyan H. Petkov, Oxana Drofa, and Mauro Mazzola 3 Trace Gases in the Arctic Atmosphere / Kimberly Strong, William R. Simpson, Kristof Bognar,Rodica Lindenmaier, and Sébastien Roche 4 Arctic Aerosols / Roberto Udisti, Rita Traversi, Silvia Becagli, Claudio Tomasi,Mauro Mazzola, Angelo Lupi, and Patricia K. Quinn 5 A Climatological Overview of Arctic Clouds / Abhay Devasthale, Joseph Sedlar, Michael Tjernström,and Alexander Kokhanovsky 6 Arctic Ice Fog: Its Microphysics and Prediction / Ismail Gultepe, Andrew J. Heymsfield, and Martin Gallagher 7 Polar Stratospheric Clouds in the Arctic / Francesco Cairo and Tiziana Colavitto 8 Noctilucent Clouds: General Properties and Remote Sensing / Christian von Savigny, Gerd Baumgarten, and Franz-Josef Lübkenix 9 Remote Sensing of Arctic Atmospheric Aerosols / Alexander Kokhanovsky, Claudio Tomasi, Alexander Smirnov,Andreas Herber, Roland Neuber, André Ehrlich, Angelo Lupi, Boyan H. Petkov, Mauro Mazzola, Christoph Ritter, Carlos Toledano,Thomas Carlund, Vito Vitale, Brent Holben, Tymon Zielinski,Simon Bélanger, Pierre Larouche, Stefan Kinne, Vladimir Radionov,Manfred Wendisch, Jason L. Tackett, and David M. Winker 10 Radiation in the Arctic Atmosphere and Atmosphere –Cryosphere Feedbacks / Claudio Tomasi, Boyan H. Petkov, Angelo Lupi, Mauro Mazzola,Christian Lanconelli, and Ismail Gultepe 11 Climate Change in the Arctic / Torben Koenigk, Jeff Key, and Timo Vihma Index
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  • 4
    Monograph available for loan
    Monograph available for loan
    London ; New York : Routledge
    Call number: PIK N 071-00-0129
    Type of Medium: Monograph available for loan
    Pages: 407 p.
    ISBN: 0415170311
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 5
    Monograph available for loan
    Monograph available for loan
    Amsterdam _[u.a.]_ : Elsevier
    Associated volumes
    Call number: M 02.0157
    In: Methods in geochemistry and geophysics
    Type of Medium: Monograph available for loan
    Pages: xiii, 681 S.
    Edition: 1st ed.
    ISBN: 0444503102
    Series Statement: Methods in geochemistry and geophysics 33
    Classification:
    A. 2.7.
    Language: English
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 6
    Monograph available for loan
    Monograph available for loan
    Amsterdam [u.a.] : Elsevier
    Associated volumes
    Call number: 12438 ; 12286
    In: Methods in geochemistry and geophysics
    Type of Medium: Monograph available for loan
    Pages: XIV, 595 S. : graph. Darst.
    ISBN: 0444418636
    Series Statement: Methods in geochemistry and geophysics 15
    Location: Upper compact magazine
    Location: Upper compact magazine
    Branch Library: GFZ Library
    Branch Library: GFZ Library
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  • 7
    Monograph available for loan
    Monograph available for loan
    Amsterdam [u.a.] : Elsevier
    Associated volumes
    Call number: 13213
    In: Methods in geochemistry and geophysics
    Type of Medium: Monograph available for loan
    Pages: XXI, 685 S. : graph. Darst.
    ISBN: 0444420320
    Series Statement: Methods in geochemistry and geophysics 16
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 8
    Monograph available for loan
    Monograph available for loan
    Amsterdam [u.a.] : Elsevier
    Associated volumes
    Call number: M 02.0155
    In: Methods in geochemistry and geophysics
    Type of Medium: Monograph available for loan
    Edition: 1st ed.
    ISBN: 0444500944
    Series Statement: Methods in geochemistry and geophysics 34
    Classification:
    A. 2.7.
    Language: English
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 9
    Call number: SR 90.0001(1222-B)
    In: U.S. Geological Survey bulletin
    Type of Medium: Series available for loan
    Pages: III, B-28 S. + 2 pl.
    Series Statement: U.S. Geological Survey bulletin 1222-B
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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  • 10
    Call number: SR 90.0001(1211-E)
    In: U.S. Geological Survey bulletin
    Type of Medium: Series available for loan
    Pages: IV, E-24 S. + 1 pl.
    Series Statement: U.S. Geological Survey bulletin 1211-E
    Language: English
    Location: Lower compact magazine
    Branch Library: GFZ Library
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