ISSN:
1573-8221
Keywords:
thyroid hormones
;
malic enzyme gene
;
structural organization
;
transcription
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Functionally different chromatin fractions have been isolated whose DNAs are used in hybridization with32P-labeled fragments of the malic enzyme gene. In thyroidectomized animals, homologs of the malic enzyme gene are found predominantly in the transcriptionally inactive chromatin fraction. In triiodothyronine-treated rats, the most intense hybridization signals are obtained from the chromatin fraction DNA hypersensitive to micrococcal nuclease and from DNA associated with the nuclear matrix. Thus, induction of the malic enzyme mRNA with triiodothyronine is attended by rearrangements at the higher levels of DNA packing.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445162
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