ISSN:
1573-4935
Keywords:
erythrocyte
;
kolaviron
;
CCl4
;
Ca2+-ATPase
;
lipid peroxidation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The possible protective effect of kolaviron on rat erythrocytes followingsimultaneous administration of kolaviron (100 mg/kg of body weight/day) withcarbon tetrachloride CCl4 (1.195 g/kg of body weight/day) by separateintraperitoneal injections was investigated. Kolaviron, a biflavonoid fraction of the defatted alcoholic extract ofGarcinia kola seed, inhibits the accumulation of lipid peroxidationproducts in erythrocytes. A significant reduction (p〉0.05) by about34% of lipid peroxidation products was observed in erythrocytes of ratstreated simultaneously with CCl4 and kolaviron when compared to CCl4-treatedrats. Similarly, the significant increase (p〉0.05) in membranecholesterol observed in CCl4-treated rats was significantly decreased(p〉0.05) in rats treated simultaneously with CCl4 andkolaviron. Therefore, there was no significant difference (p〉0.05) incholesterol–phospholipid ratio (C/P) of rats treated simultaneouslywith CCl4 and kolaviron, and the controls. Thus, kolaviron normalizes theCCl4-induced change in erythrocyte membrane composition. In addition, kolaviron antagonizes the effect of CCl4 on the activity ofthe membrane bound enzyme, Ca2+-ATPase. These results suggest thatkolaviron protects erythrocyte membranes from free radical attack, on bothlipids and proteins.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026488823157
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