ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Publication Date: 2009-10-12
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2019
    Description: 〈p〉A recent article in 〈i〉Science Advances〈/i〉 described the striking discovery that the commensal 〈i〉Staphylococcus epidermidis〈/i〉 strain MO34 displays antimicrobial and antitumor activities by producing a small molecule, identified as the nucleobase analog 6-〈i〉N〈/i〉-hydroxylaminopurine (6-HAP). However, in contradiction to the literature, the authors claimed that 6-HAP is nonmutagenic and proposed that the toxic effect of 6-HAP results from its ability to inhibit, in its base form, DNA synthesis. To resolve the discrepancy, we proved by genetic experiments with bacteria and yeast that extracts of MO34 do contain a mutagenic compound whose effects are identical to chemically synthesized 6-HAP. The MO34 extract induced the same mutation spectrum as authentic 6-HAP. Notably, the toxic and mutagenic effects of both synthetic and MO34-derived 6-HAP depended on conversion to the corresponding nucleotide. The nucleobase 6-HAP does not inhibit DNA synthesis in vitro, and we conclude that 6-HAP exerts its biological activity when incorporated into DNA.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2015-07-14
    Description: The utilization of polarized targets in scattering experiments has become a common practice in many major accelerator laboratories. Noble gases are especially suitable for such applications, since they can be easily hyper-polarized using spin exchange or metastable pumping techniques. Polarized helium-3 is a very popular target because it often serves as an effective polarized neutron due to its simple nuclear structure. A favorite cell material to generate and store polarized helium-3 is GE-180, a relatively dense aluminosilicate glass. In this paper, we present a Faraday rotation method, using a new triple modulation technique, where the measurement of the Verdet constants of SF57 flint glass, pyrex glass, and air was tested. The sensitivity obtained shows that this technique may be implemented in future cell wall characterization and thickness measurements. We also discuss the first ever extraction of the Verdet constant of GE-180 glass for four wavelength values of 632 nm, 773 nm, 1500 nm, and 1547 nm, whereupon the expected 1/λ 2 dependence was observed.
    Print ISSN: 0034-6748
    Electronic ISSN: 1089-7623
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2013-10-09
    Description: Genome-wide association studies of complex traits often are complicated by relatedness among individuals. Ignoring or inappropriately accounting for relatedness often results in inflated type I error rates. Either genotype or pedigree data can be used to estimate relatedness for use in mixed-models when undertaking quantitative trait locus mapping. We performed simulations to investigate methods for controlling type I error and optimizing power considering both full and partial pedigrees and, similarly, both sparse and dense marker coverage; we also examined real data sets. (1) When marker density was low, estimating relatedness by genotype data alone failed to control the type I error rate; (2) this was resolved by combining both genotype and pedigree data. (3) When sufficiently dense marker data were used to estimate relatedness, type I error was well controlled and power increased; however, (4) this was only true when the relatedness was estimated using genotype data that excluded genotypes on the chromosome currently being scanned for a quantitative trait locus.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2012-05-22
    Description: : Mixed model-based approaches to genome-wide association studies (GWAS) of binary traits in related individuals can account for non-genetic risk factors in an integrated manner. However, they are technically challenging. GLOGS (Genome-wide LOGistic mixed model/Score test) addresses such challenges with efficient statistical procedures and a parallel implementation. GLOGS has high power relative to alternative approaches as risk covariate effects increase, and can complete a GWAS in minutes. Availability: Source code and documentation are provided at http://www.bioinformatics.org/~stanhope/GLOGS . Contact: sstanhop@bsd.uchicago.edu Supplementary information: Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2019-07-12
    Description: Marshall Space Flight Center is essential to human space exploration and our work is a catalyst for ongoing technological development. As we address the challenges facing human deep space exploration, we advance new technologies and applications here on Earth, expand scientific knowledge and discovery, create new economic opportunities, and continue to lead global space exploration.
    Keywords: General
    Type: NASA/TM-2017-219502 , M-1427 , MSFC-E-DAA-TN41778
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2019-08-27
    Description: In September 2011, the Atmosphere Resource Recovery and Environmental Monitoring (ARREM) project was commissioned by NASA's Advanced Exploration Systems program to advance Atmosphere Revitalization Subsystem (ARS) and Environmental Monitoring Subsystem (EMS) technologies for enabling future crewed space exploration missions beyond low Earth orbit. The ARREM project's period of performance covered U.S. Government fiscal years 2012-2014. The ARREM project critically assessed the International Space Station (ISS) ARS and EMS architectures and process technologies as the foundation for an architecture suitable for deep space exploration vehicles. The project's technical content included technical tasks focused on improving the reliability and life cycle cost of ARS and EMS technologies as well as reducing future flight project developmental risk and design, development, test, and evaluation costs. Targeted technology development and maturation tasks, including key technical trade assessments, were accomplished and integrated ARS architectures were demonstrated. The ARREM project developed, demonstrated, and tested leading process technology candidates and subsystem architectures that met or exceeded key figures of merit, addressed capability gaps, and significantly improved the efficiency, safety, and reliability over the state-of-the-art ISS figures of merit. Promising EMS instruments were developed and functionally demonstrated in a simulated cabin environment. The project's technical approach and results are described and recommendations for continued development are provided.
    Keywords: Man/System Technology and Life Support
    Type: NASA/TP-2016-218228 , M-1419
    Format: application/pdf
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...