Publication Date:
1985-05-03
Description:
In contrast to other kinds of phospholipases, phospholipases D that are toxic for humans and animals are not commonly encountered as constituents of venoms or as products of pathogenic microorganisms. Toxic phospholipases D are present, however, in the venom of the brown recluse spider (Loxosceles reclusa) and in supernatants or filtrates of cultures of Corynebacterium pseudotuberculosis. Although the two enzyme toxins are derived from phylogenetically disparate entities, they are similar in molecular weight, charge, substrate specificity, and in several biological activities. They are immunologically distinguishable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernheimer, A W -- Campbell, B J -- Forrester, L J -- New York, N.Y. -- Science. 1985 May 3;228(4699):590-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3983643" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Arthropod Venoms/*pharmacology
;
Bacterial Toxins/immunology/*pharmacology
;
*Corynebacterium
;
Cross Reactions
;
Erythrocytes/drug effects
;
Hemolysis/drug effects
;
Phospholipases/pharmacology
;
Sheep
;
Sphingomyelin Phosphodiesterase/pharmacology
;
Spider Venoms/immunology/*pharmacology
;
Spiders
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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