Publication Date:
1982-12-10
Description:
The noncytopathic lymphocytic choriomeningitis virus displays a tropism for the anterior lobe of the murine pituitary gland. Virus replicates in cells that make growth hormone. This results in a diminished synthesis of growth hormone with a concomitant clinical picture of retarded growth and hypoglycemia. However, there is no morphologic evidence of either cell necrosis or inflammation in the anterior lobe of the pituitary. Hence, during infection in vivo, a noncytopathic virus may turn off the "differentiation" or "luxury" function of a cell while not killing that cell (loss of vital function). This is turn can disrupt homeostasis and cause disease. This model illustrates a novel way whereby viruses may cause disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oldstone, M B -- Sinha, Y N -- Blount, P -- Tishon, A -- Rodriguez, M -- von Wedel, R -- Lampert, P W -- AI-09484/AI/NIAID NIH HHS/ -- CA-33448/CA/NCI NIH HHS/ -- NS-12428/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1125-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146898" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Viral/analysis
;
Growth
;
Growth Hormone/*biosynthesis
;
*Homeostasis
;
Lymphocytic Choriomeningitis/*physiopathology
;
Lymphocytic choriomeningitis virus/immunology/*physiology
;
Mice
;
Pituitary Gland, Anterior/microbiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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