Publication Date:
1986-05-16
Description:
Hepatitis delta virus (HDV) is a replication-defective etiological agent of hepatitis that requires hepatitis B virus (HBV) as a helper. A complementary DNA (cDNA) fragment of the RNA genome of HDV was cloned into the plasmid vector pBR322, and the primary nucleotide sequence and predicted protein products of the cDNA fragment were determined. This cloned cDNA fragment has been used as a sensitive radioactive probe for the detection of HDV RNA in the serum of patients with either acute or chronic HDV infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Denniston, K J -- Hoyer, B H -- Smedile, A -- Wells, F V -- Nelson, J -- Gerin, J L -- N01-AI-22665/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 May 16;232(4752):873-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3704630" target="_blank"〉PubMed〈/a〉
Keywords:
Base Sequence
;
Cloning, Molecular
;
Hepatitis D/*diagnosis/microbiology
;
Hepatitis Delta Virus/*genetics
;
Humans
;
Nucleic Acid Hybridization
;
Pan troglodytes
;
RNA, Viral/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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