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  • 1
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    Evidence for variable, correlated X-ray and optical/IR extinction towards the nearby, pre-main-sequence binary TWA 30 (2016)
    Oxford University Press
    Details
    Publication Date: 2016-05-01
    Description: We present contemporaneous XMM–Newton X-ray and ground-based optical/near-IR spectroscopic observations of the nearby ( D 42 pc), low-mass (mid-M) binary system TWA 30A and 30B. The components of this wide (separation ~3400 au) binary are notable for their nearly edge-on disc viewing geometries, high levels of variability, and evidence for collimated stellar outflows. We obtained XMM–Newton X-ray observations of TWA 30A and 30B in 2011 June and July, accompanied (respectively) by Infrared Telescope Facility SpeX (near-IR) and VLT XSHOOTER (visible/near-IR) spectroscopy obtained within ~20 h of the X-ray observations. TWA 30A was detected in both XMM–Newton observations at relatively faint intrinsic X-ray luminosities ( L X ~ 8 x 10 27 erg s –1 ) compared to stars of similar mass and age. The intrinsic (0.15–2.0 keV) X-ray luminosities measured in 2011 had decreased by a factor 20–100 relative to a 1990 ( ROSAT ) X-ray detection. TWA 30B was not detected, and we infer an upper limit on its X-ray Luminosity of L X 3.0 x 10 27  erg s –1 . We measured a decrease in visual extinction towards TWA 30A (from A V 14.9 to A V 4.7) between the two 2011 observing epochs, and we find evidence for a corresponding significant decrease in X-ray absorbing column ( N H ). The apparent correlated change in A V and N H is suggestive of variable obscuration of the stellar photosphere by disc material composed of both gas and dust. However, in both observations, the inferred N H to A V ratio is lower than that typical of the interstellar medium, suggesting that the disc is either depleted of gas or is deficient in metals in the gas phase.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 2
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    Reprogramming towards pluripotency requires AID-dependent DNA demethylation (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-12-23
    Description: Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes possible derivation of patient-specific stem cells for regenerative medicine. However, iPS cell generation is asynchronous and slow (2-3 weeks), the frequency is low (〈0.1%), and DNA demethylation constitutes a bottleneck. To determine regulatory mechanisms involved in reprogramming, we generated interspecies heterokaryons (fused mouse embryonic stem (ES) cells and human fibroblasts) that induce reprogramming synchronously, frequently and fast. Here we show that reprogramming towards pluripotency in single heterokaryons is initiated without cell division or DNA replication, rapidly (1 day) and efficiently (70%). Short interfering RNA (siRNA)-mediated knockdown showed that activation-induced cytidine deaminase (AID, also known as AICDA) is required for promoter demethylation and induction of OCT4 (also known as POU5F1) and NANOG gene expression. AID protein bound silent methylated OCT4 and NANOG promoters in fibroblasts, but not active demethylated promoters in ES cells. These data provide new evidence that mammalian AID is required for active DNA demethylation and initiation of nuclear reprogramming towards pluripotency in human somatic cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906123/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906123/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bhutani, Nidhi -- Brady, Jennifer J -- Damian, Mara -- Sacco, Alessandra -- Corbel, Stephane Y -- Blau, Helen M -- AG009521/AG/NIA NIH HHS/ -- AG024987/AG/NIA NIH HHS/ -- AI007328/AI/NIAID NIH HHS/ -- R01 AG009521/AG/NIA NIH HHS/ -- R01 AG009521-25/AG/NIA NIH HHS/ -- R01 AG024987/AG/NIA NIH HHS/ -- R01 AG024987-05/AG/NIA NIH HHS/ -- T32 AI007328/AI/NIAID NIH HHS/ -- U01 HL100397/HL/NHLBI NIH HHS/ -- England -- Nature. 2010 Feb 25;463(7284):1042-7. doi: 10.1038/nature08752.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5175, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20027182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Fusion ; Cell Line ; Cells, Cultured ; Cellular Reprogramming/genetics/*physiology ; Chromatin Immunoprecipitation ; Cytidine Deaminase/deficiency/genetics/*metabolism ; DNA/chemistry/genetics/metabolism ; *DNA Methylation ; DNA Replication ; Embryonic Stem Cells/cytology/metabolism ; Fibroblasts/cytology/metabolism ; Gene Expression Regulation ; Gene Knockdown Techniques ; Homeodomain Proteins/genetics ; Humans ; Induced Pluripotent Stem Cells/*cytology/enzymology/*metabolism ; Lung/cytology/embryology ; Mice ; Models, Biological ; Octamer Transcription Factor-3/genetics ; Promoter Regions, Genetic/genetics ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Self-renewal and expansion of single transplanted muscle stem cells (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-09-23
    Description: Adult muscle satellite cells have a principal role in postnatal skeletal muscle growth and regeneration. Satellite cells reside as quiescent cells underneath the basal lamina that surrounds muscle fibres and respond to damage by giving rise to transient amplifying cells (progenitors) and myoblasts that fuse with myofibres. Recent experiments showed that, in contrast to cultured myoblasts, satellite cells freshly isolated or satellite cells derived from the transplantation of one intact myofibre contribute robustly to muscle repair. However, because satellite cells are known to be heterogeneous, clonal analysis is required to demonstrate stem cell function. Here we show that when a single luciferase-expressing muscle stem cell is transplanted into the muscle of mice it is capable of extensive proliferation, contributes to muscle fibres, and Pax7(+)luciferase(+) mononucleated cells can be readily re-isolated, providing evidence of muscle stem cell self-renewal. In addition, we show using in vivo bioluminescence imaging that the dynamics of muscle stem cell behaviour during muscle repair can be followed in a manner not possible using traditional retrospective histological analyses. By imaging luciferase activity, real-time quantitative and kinetic analyses show that donor-derived muscle stem cells proliferate and engraft rapidly after injection until homeostasis is reached. On injury, donor-derived mononucleated cells generate massive waves of cell proliferation. Together, these results show that the progeny of a single luciferase-expressing muscle stem cell can both self-renew and differentiate after transplantation in mice, providing new evidence at the clonal level that self-renewal is an autonomous property of a single adult muscle stem cell.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919355/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919355/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sacco, Alessandra -- Doyonnas, Regis -- Kraft, Peggy -- Vitorovic, Stefan -- Blau, Helen M -- AG009521/AG/NIA NIH HHS/ -- AG024987/AG/NIA NIH HHS/ -- R01 AG009521/AG/NIA NIH HHS/ -- R01 AG009521-24/AG/NIA NIH HHS/ -- R01 AG009521-25/AG/NIA NIH HHS/ -- R01 AG020961/AG/NIA NIH HHS/ -- R01 AG020961-06A2/AG/NIA NIH HHS/ -- R01 AG020961-07/AG/NIA NIH HHS/ -- R01 AG024987/AG/NIA NIH HHS/ -- R01 AG024987-04/AG/NIA NIH HHS/ -- R01 AG024987-05/AG/NIA NIH HHS/ -- England -- Nature. 2008 Nov 27;456(7221):502-6. doi: 10.1038/nature07384. Epub 2008 Sep 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Baxter Laboratory in Genetic Pharmacology, Department of Microbiology and Immunology, Stem Cell Institute, Stanford University School of Medicine, Stanford, California 94305-5175, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18806774" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD/metabolism ; Antigens, CD34/metabolism ; Cell Proliferation ; Cells, Cultured ; Homeostasis ; Integrin alpha Chains/metabolism ; Luminescent Measurements ; Mice ; Muscle Fibers, Skeletal/cytology ; Muscles/*cytology ; *Regeneration ; Satellite Cells, Skeletal Muscle/*cytology ; *Stem Cell Transplantation ; Stem Cells/*cytology/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-07-22
    Description: Stem cells that naturally reside in adult tissues, such as muscle stem cells (MuSCs), exhibit robust regenerative capacity in vivo that is rapidly lost in culture. Using a bioengineered substrate to recapitulate key biophysical and biochemical niche features in conjunction with a highly automated single-cell tracking algorithm, we show that substrate elasticity is a potent regulator of MuSC fate in culture. Unlike MuSCs on rigid plastic dishes (approximately 10(6) kilopascals), MuSCs cultured on soft hydrogel substrates that mimic the elasticity of muscle (12 kilopascals) self-renew in vitro and contribute extensively to muscle regeneration when subsequently transplanted into mice and assayed histologically and quantitatively by noninvasive bioluminescence imaging. Our studies provide novel evidence that by recapitulating physiological tissue rigidity, propagation of adult muscle stem cells is possible, enabling future cell-based therapies for muscle-wasting diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929271/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929271/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, P M -- Havenstrite, K L -- Magnusson, K E G -- Sacco, A -- Leonardi, N A -- Kraft, P -- Nguyen, N K -- Thrun, S -- Lutolf, M P -- Blau, H M -- 2 T32 HD007249/HD/NICHD NIH HHS/ -- 52005886/Howard Hughes Medical Institute/ -- AG009521/AG/NIA NIH HHS/ -- AG020961/AG/NIA NIH HHS/ -- CA09151/CA/NCI NIH HHS/ -- HL096113/HL/NHLBI NIH HHS/ -- R01 AG009521/AG/NIA NIH HHS/ -- R01 AG009521-25/AG/NIA NIH HHS/ -- R01 AG020961/AG/NIA NIH HHS/ -- R01 AG020961-06A2/AG/NIA NIH HHS/ -- R01 AG020961-07/AG/NIA NIH HHS/ -- R01 HL096113/HL/NHLBI NIH HHS/ -- R01 HL096113-03/HL/NHLBI NIH HHS/ -- T32 CA009151/CA/NCI NIH HHS/ -- T32 CA009151-35/CA/NCI NIH HHS/ -- T32 HD007249/HD/NICHD NIH HHS/ -- T32 HD007249-25/HD/NICHD NIH HHS/ -- U01 HL100397/HL/NHLBI NIH HHS/ -- U01 HL100397-01/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2010 Aug 27;329(5995):1078-81. doi: 10.1126/science.1191035. Epub 2010 Jul 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20647425" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Cell Count ; Cell Culture Techniques/*methods ; Cell Death ; Cell Differentiation ; Cell Division ; Cell Lineage ; Cell Separation ; Cell Survival ; Cells, Cultured ; Elastic Modulus ; Hydrogels ; Mice ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Mice, SCID ; Mice, Transgenic ; Muscle Fibers, Skeletal/*cytology/physiology ; Muscle, Skeletal/*cytology ; Polyethylene Glycols ; Regeneration ; Satellite Cells, Skeletal Muscle/cytology ; Stem Cell Niche/*physiology ; Stem Cell Transplantation ; Stem Cells/cytology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Fast TiO2 Sensitization Using the Semisquaric Acid as Anchoring Group (2013)
    Hindawi
    Details
    Publication Date: 2013-11-08
    Description: Metal-free dye molecules for dye-sensitized solar cells application can avoid some of the typical drawbacks of common metal-based sensitizers, that are high production costs, relatively low molar extinction coefficient in the visible region, limited availability of precursors, and waste disposal issues. Recently we have proposed an innovative organic dye based on a simple hemi-squaraine molecule (CT1). In the present work, the effect of the sensitization time of the TiO2 photoelectrode in the dye solution is studied with the aim of optimizing the performance of CT1-based DSCs. Moreover, the addition of the chenodeoxycholic acid (CDCA) as coadsorbent in the dye solution at different concentrations is investigated. Both CT1-sensitized mesoporous TiO2 photoanodes and complete solar cells have been fully characterized in their electrical and absorption properties. We have found that the best photoconversion performances are obtained with 1 hour of impregnation time and a 1 mM CDCA concentration. The very fast kinetics in dye adsorption, with optimal sensitization steps almost 15 times faster than conventional Ru-based sensitizers, confirms the theoretical predictions and indicates a strong interaction of the semisquaric acid group with the anatase surface. This result suggests that this small molecule can be a promising sensitizer even in a continuous industrial process.
    Print ISSN: 1110-662X
    Electronic ISSN: 1687-529X
    Topics: Electrical Engineering, Measurement and Control Technology , Energy, Environment Protection, Nuclear Power Engineering
    Published by Hindawi
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of site-specific isotopic substitutions on transport coefficients of liquid methanol (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 2568-2574 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A new approach is suggested for studying the nature of molecular transport in simple liquids, which makes use of site-specific isotopic substitutions. Its application represents the first systematic experimental study of a theoretically predicted correlation between transport coefficients in liquids and molecular moments of inertia. For this purpose, we have determined the viscosities and self-diffusion coefficients at 25 °C of normal methanol and seven isotopically labeled methanol species: CH3OD, CD3OH, CD3OD, CH2DOH, CHD2OH, CHD2OD, and 13CH3OH. Except for 12C/13C substitution, the observed isotope effects are significantly larger than predicted by a square root of mass dependence, but are well correlated with the square roots of the moments of inertia. The results give strong evidence that translation–rotation coupling influences the transport processes in methanol, thus confirming earlier interpretations of isotope effects upon the transport in water.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.457016
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  • 7
    Electronic Resource
    Electronic Resource
    Apparent molar volumes of tetraalkylammonium iodides in sulfolane at 30, 40 and 50^o C
    Amsterdam : Elsevier
    Electrochimica Acta 26 (1981), S. 747-750 
    Details
    ISSN: 0013-4686
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0013-4686(81)90032-3
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  • 8
    Electronic Resource
    Electronic Resource
    Transference numbers in concentrated sodium chloride solutions
    Amsterdam : Elsevier
    Electrochimica Acta 24 (1979), S. 1013-1017 
    Details
    ISSN: 0013-4686
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0013-4686(79)87099-1
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  • 9
    Electronic Resource
    Electronic Resource
    New cationic hydrido and hydrido-dinitrogen complexes of iron
    Amsterdam : Elsevier
    Coordination Chemistry Reviews 8 (1972), S. 77-79 
    Details
    ISSN: 0010-8545
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0010-8545(00)80054-5
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  • 10
    Electronic Resource
    Electronic Resource
    Hydrido-complexes of rhodium(III) with tertiary phosphines
    Amsterdam : Elsevier
    Coordination Chemistry Reviews 1 (1966), S. 234-238 
    Details
    ISSN: 0010-8545
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0010-8545(00)80176-9
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