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  • 1
    Call number: 10.1144/GSL.SP.1984.017.01.68 (e-book)
    In: Special publications / the Geological Society, London, Volume 17
    Description / Table of Contents: The Eastern Mediterranean is an excellent ‘field laboratory’ for the study of fundamental processes of continental rifting, passive margin development, ophiolite generation and emplacement and the tectonic, magmatic and sedimentary effects of continental collision. Since its publication in 1984, The Geological Evolution of the Eastern Mediterranean has proved to be an invaluable aid to research in this important region. Many of the papers are classics that report basic data and tectonic interpretations that still remain valid today. The individual papers summarize a large amount of international research that was carried out in the Eastern Mediterranean region during the previous decade. This volume was the first integrated overview of one of the world’s most complex orogenic areas. The editors have added an outline of the main research developments since 1984 and key references to the more recent literature; several figures have been redrawn and the volume is now fully indexed.
    Type of Medium: 12
    Pages: 1 Online-Ressource (VII, 836 Seiten) , Illustrationen
    ISBN: 0632011440 , 1-897799-66-7 , 1897799667
    Series Statement: Special publications / the Geological Society, London 17
    Language: English
    Note: Contents Recent research developments / Geological Society, London, Special Publications, 17:xi-xii, doi:10.1144/GSL.SP.1984.017.01.01 --- A. H. F. Robertson and J. E. Dixon: Introduction: aspects of the geological evolution of the Eastern Mediterranean / Geological Society, London, Special Publications, 17:1-74, doi:10.1144/GSL.SP.1984.017.01.02 --- 1. Palaeotethys --- Editor’s introduction / Geological Society, London, Special Publications, 17:75-76, doi:10.1144/GSL.SP.1984.017.01.03 --- A. M. C. Şengör, Y. Yılmaz, and O. Sungurlu: Tectonics of the Mediterranean Cimmerides: nature and evolution of the western termination of Palaeo-Tethys / Geological Society, London, Special Publications, 17:77-112, doi:10.1144/GSL.SP.1984.017.01.04 --- Olivier Monod and Ergün Akay: Evidence for a Late Triassic-Early Jurassic orogenic event in the Taurides / Geological Society, London, Special Publications, 17:113-122, doi:10.1144/GSL.SP.1984.017.01.05 --- I. E. Kerey: Facies and tectonic setting of the Upper Carboniferous rocks of Northwestern Turkey / Geological Society, London, Special Publications, 17:123-128, doi:10.1144/GSL.SP.1984.017.01.06 --- E. Demirtaşh: Stratigraphic evidence of Variscan and early Alpine tectonics in Southern Turkey / Geological Society, London, Special Publications, 17:129-145, doi:10.1144/GSL.SP.1984.017.01.07 --- 2. Neoththys --- Levant and North African offshore: Editor’s introduction / Geological Society, London, Special Publications, 17:147-149, doi:10.1144/GSL.SP.1984.017.01.08 --- M. Delaune-Mayere: Evolution of a Mesozoic passive continental margin: Baër-Bassit (NW Syria) / Geological Society, London, Special Publications, 17:151-159, doi:10.1144/GSL.SP.1984.017.01.09 --- G. Sestini: Tectonic and sedimentary history of the NE African margin (Egypt—Libya) / Geological Society, London, Special Publications, 17:161-175, doi:10.1144/GSL.SP.1984.017.01.10 --- Gdaliahu Gvirtzman and Tuvia Weissbrod: The Hercynian Geanticline of Helez and the Late Palaeozoic history of the Levant / Geological Society, London, Special Publications, 17:177-186, doi:10.1144/GSL.SP.1984.017.01.11 --- Z. Garfunkel and B. Derin: Permian-early Mesozoic tectonism and continental margin formation in Israel and its implications for the history of the Eastern Mediterranean / Geological Society, London, Special Publications, 17:187-201, doi:10.1144/GSL.SP.1984.017.01.12 --- Yehezkeel Druckman: Evidence for Early-Middle Triassic faulting and possible rifting from the Helez Deep Borehole in the coastal plain of Israel / Geological Society, London, Special Publications, 17:203-212, doi:10.1144/GSL.SP.1984.017.01.13 --- Abdulkader M. Abed: Emergence of Wadi Mujib (Central Jordan) during Lower Cenomanian time and its regional tectonic implications / Geological Society, London, Special Publications, 17:213-216, doi:10.1144/GSL.SP.1984.017.01.14 --- F. Hirsch: The Arabian sub-plate during the Mesozoic / Geological Society, London, Special Publications, 17:217-223, doi:10.1144/GSL.SP.1984.017.01.15 --- Michel Delaloye and Jean-Jacques Wagner: Ophiolites and volcanic activity near the western edge of the Arabian plate / Geological Society, London, Special Publications, 17:225-233, doi:10.1144/GSL.SP.1984.017.01.16 --- 3. Neotethys: Turkey --- Editor’s introduction / Geological Society, London, Special Publications, 17:235-240, doi:10.1144/GSL.SP.1984.017.01.17 --- A. Poisson: The extension of the Ionian trough into southwestern Turkey / Geological Society, London, Special Publications, 17:241-249, doi:10.1144/GSL.SP.1984.017.01.18 --- A. H. F. Robertson and N. H. Woodcock: The SW segment of the Antalya Complex, Turkey as a Mesozoic-Tertiary Tethyan continental margin / Geological Society, London, Special Publications, 17:251-271, doi:10.1144/GSL.SP.1984.017.01.19 --- J. W. F. Waldron: Structural history of the Antalya Complex in the ‘Isparta angle’, Southwest Turkey / Geological Society, London, Special Publications, 17:273-286, doi:10.1144/GSL.SP.1984.017.01.20 --- A. B. Hayward: Miocene clastic sedimentation related to the emplacement of the Lycian Nappes and the Antalya Complex, S.W. Turkey / Geological Society, London, Special Publications, 17:287-300, doi:10.1144/GSL.SP.1984.017.01.21 --- Hubert Whitechurch, Thierry Juteau, and Raymond Montigny: Role of the Eastern Mediterranean ophiolites (Turkey, Syria, Cyprus) in the history of the Neo-Tethys / Geological Society, London, Special Publications, 17:301-317, doi:10.1144/GSL.SP.1984.017.01.22 --- Ingrid Reuber: Mylonitic ductile shear zones within tectonites and cumulates as evidence for an oceanic transform fault in the Antalya ophiolite, S.W. Turkey / Geological Society, London, Special Publications, 17:319-334, doi:10.1144/GSL.SP.1984.017.01.23 --- Pınar O. Yılmaz: Fossil and K-Ar data for the age of the Antalya complex, S W Turkey / Geological Society, London, Special Publications, 17:335-347, doi:10.1144/GSL.SP.1984.017.01.24 --- L. E. Ricou, J. Marcoux, and H. Whitechurch: The Mesozoic organization of the Taurides: one or several ocean basins? / Geological Society, London, Special Publications, 17:349-359, doi:10.1144/GSL.SP.1984.017.01.25 --- A. Michard, H. Whitechurch, L. E. Ricou, R. Montigny, and E. Yazgan: Tauric subduction (Malatya-Elazıǧ provinces) and its bearing on tectonics of the Tethyan realm in Turkey / Geological Society, London, Special Publications, 17:361-373, doi:10.1144/GSL.SP.1984.017.01.26 --- G. Aktaş and A. H. F. Robertson: The Maden Complex, SE Turkey: evolution of a Neotethyan active margin / Geological Society, London, Special Publications, 17:375-402, doi:10.1144/GSL.SP.1984.017.01.27 --- Cahit Helvaci and William L. Griffin: Rb-Sr geochronology of the Bitlis Massif, Avnik (Bingöl) area, S.E. Turkey / Geological Society, London, Special Publications, 17:403-413, doi:10.1144/GSL.SP.1984.017.01.28 --- Ömer T. Akıncı: The Eastern Pontide volcano-sedimentary belt and associated massive sulphide deposits / Geological Society, London, Special Publications, 17:415-428, doi:10.1144/GSL.SP.1984.017.01.29 --- A. I. Okay and N. Özgül: HP/LT metamorphism and the structure of the Alanya Massif, Southern Turkey: an allochthonous composite tectonic sheet / Geological Society, London, Special Publications, 17:429-439, doi:10.1144/GSL.SP.1984.017.01.30 --- Teoman N. Norman: The role of the Ankara Melange in the development of Anatolia (Turkey) / Geological Society, London, Special Publications, 17:441-447, doi:10.1144/GSL.SP.1984.017.01.31 --- Ayla Tankut: Basic and ultrabasic rocks from the Ankara Melange, Turkey / Geological Society, London, Special Publications, 17:449-454, doi:10.1144/GSL.SP.1984.017.01.32 --- A. I. Okay: Distribution and characteristics of the north-west Turkish blueschists / Geological Society, London, Special Publications, 17:455-466, doi:10.1144/GSL.SP.1984.017.01.33 --- N. Görür, F.Y. Oktay, İ. Seymen, and A. M. C. Şengör: Palaeotectonic evolution of the Tuzgölü basin complex, Central Turkey: sedimentary record of a Neo-Tethyan closure / Geological Society, London, Special Publications, 17:467-482, doi:10.1144/GSL.SP.1984.017.01.34 --- J. P. Lauer: Geodynamic evolution of Turkey and Cyprus based on palaeomagnetic data / Geological Society, London, Special Publications, 17:483-491, doi:10.1144/GSL.SP.1984.017.01.35 --- 4. Neotethys: Greece and the Balkans --- Editor’s introduction / Geological Society, London, Special Publications, 17:493-498, doi:10.1144/GSL.SP.1984.017.01.36 --- Robert Hall, M. G. Audley-Charles, and D. J. Carter: The significance of Crete for the evolution of the Eastern Mediterranean / Geological Society, London, Special Publications, 17:499-516, doi:10.1144/GSL.SP.1984.017.01.37 --- Michel Bonneau: Correlation of the Hellenide nappes in the south-east Aegean and their tectonic reconstruction / Geological Society, London, Special Publications, 17:517-527, doi:10.1144/GSL.SP.1984.017.01.38 --- M. Okrusch, P. Richter
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  • 2
    Call number: 9/MR 90.0950
    In: Special publications / the Geological Society, London, Volume 17
    Description / Table of Contents: The Eastern Mediterranean is an excellent ‘field laboratory’ for the study of fundamental processes of continental rifting, passive margin development, ophiolite generation and emplacement and the tectonic, magmatic and sedimentary effects of continental collision. Since its publication in 1984, The Geological Evolution of the Eastern Mediterranean has proved to be an invaluable aid to research in this important region. Many of the papers are classics that report basic data and tectonic interpretations that still remain valid today. The individual papers summarize a large amount of international research that was carried out in the Eastern Mediterranean region during the previous decade. This volume was the first integrated overview of one of the world’s most complex orogenic areas. The editors have added an outline of the main research developments since 1984 and key references to the more recent literature; several figures have been redrawn and the volume is now fully indexed.
    Type of Medium: Monograph available for loan
    Pages: VII, 836 Seiten , Illustrationen
    ISBN: 0632011440 , 1-897799-66-7 , 1897799667
    Series Statement: Special publications / the Geological Society, London 17
    Language: English
    Note: Contents Recent research developments / Geological Society, London, Special Publications, 17:xi-xii, doi:10.1144/GSL.SP.1984.017.01.01 --- A. H. F. Robertson and J. E. Dixon: Introduction: aspects of the geological evolution of the Eastern Mediterranean / Geological Society, London, Special Publications, 17:1-74, doi:10.1144/GSL.SP.1984.017.01.02 --- 1. Palaeotethys --- Editor’s introduction / Geological Society, London, Special Publications, 17:75-76, doi:10.1144/GSL.SP.1984.017.01.03 --- A. M. C. Şengör, Y. Yılmaz, and O. Sungurlu: Tectonics of the Mediterranean Cimmerides: nature and evolution of the western termination of Palaeo-Tethys / Geological Society, London, Special Publications, 17:77-112, doi:10.1144/GSL.SP.1984.017.01.04 --- Olivier Monod and Ergün Akay: Evidence for a Late Triassic-Early Jurassic orogenic event in the Taurides / Geological Society, London, Special Publications, 17:113-122, doi:10.1144/GSL.SP.1984.017.01.05 --- I. E. Kerey: Facies and tectonic setting of the Upper Carboniferous rocks of Northwestern Turkey / Geological Society, London, Special Publications, 17:123-128, doi:10.1144/GSL.SP.1984.017.01.06 --- E. Demirtaşh: Stratigraphic evidence of Variscan and early Alpine tectonics in Southern Turkey / Geological Society, London, Special Publications, 17:129-145, doi:10.1144/GSL.SP.1984.017.01.07 --- 2. Neoththys --- Levant and North African offshore: Editor’s introduction / Geological Society, London, Special Publications, 17:147-149, doi:10.1144/GSL.SP.1984.017.01.08 --- M. Delaune-Mayere: Evolution of a Mesozoic passive continental margin: Baër-Bassit (NW Syria) / Geological Society, London, Special Publications, 17:151-159, doi:10.1144/GSL.SP.1984.017.01.09 --- G. Sestini: Tectonic and sedimentary history of the NE African margin (Egypt—Libya) / Geological Society, London, Special Publications, 17:161-175, doi:10.1144/GSL.SP.1984.017.01.10 --- Gdaliahu Gvirtzman and Tuvia Weissbrod: The Hercynian Geanticline of Helez and the Late Palaeozoic history of the Levant / Geological Society, London, Special Publications, 17:177-186, doi:10.1144/GSL.SP.1984.017.01.11 --- Z. Garfunkel and B. Derin: Permian-early Mesozoic tectonism and continental margin formation in Israel and its implications for the history of the Eastern Mediterranean / Geological Society, London, Special Publications, 17:187-201, doi:10.1144/GSL.SP.1984.017.01.12 --- Yehezkeel Druckman: Evidence for Early-Middle Triassic faulting and possible rifting from the Helez Deep Borehole in the coastal plain of Israel / Geological Society, London, Special Publications, 17:203-212, doi:10.1144/GSL.SP.1984.017.01.13 --- Abdulkader M. Abed: Emergence of Wadi Mujib (Central Jordan) during Lower Cenomanian time and its regional tectonic implications / Geological Society, London, Special Publications, 17:213-216, doi:10.1144/GSL.SP.1984.017.01.14 --- F. Hirsch: The Arabian sub-plate during the Mesozoic / Geological Society, London, Special Publications, 17:217-223, doi:10.1144/GSL.SP.1984.017.01.15 --- Michel Delaloye and Jean-Jacques Wagner: Ophiolites and volcanic activity near the western edge of the Arabian plate / Geological Society, London, Special Publications, 17:225-233, doi:10.1144/GSL.SP.1984.017.01.16 --- 3. Neotethys: Turkey --- Editor’s introduction / Geological Society, London, Special Publications, 17:235-240, doi:10.1144/GSL.SP.1984.017.01.17 --- A. Poisson: The extension of the Ionian trough into southwestern Turkey / Geological Society, London, Special Publications, 17:241-249, doi:10.1144/GSL.SP.1984.017.01.18 --- A. H. F. Robertson and N. H. Woodcock: The SW segment of the Antalya Complex, Turkey as a Mesozoic-Tertiary Tethyan continental margin / Geological Society, London, Special Publications, 17:251-271, doi:10.1144/GSL.SP.1984.017.01.19 --- J. W. F. Waldron: Structural history of the Antalya Complex in the ‘Isparta angle’, Southwest Turkey / Geological Society, London, Special Publications, 17:273-286, doi:10.1144/GSL.SP.1984.017.01.20 --- A. B. Hayward: Miocene clastic sedimentation related to the emplacement of the Lycian Nappes and the Antalya Complex, S.W. Turkey / Geological Society, London, Special Publications, 17:287-300, doi:10.1144/GSL.SP.1984.017.01.21 --- Hubert Whitechurch, Thierry Juteau, and Raymond Montigny: Role of the Eastern Mediterranean ophiolites (Turkey, Syria, Cyprus) in the history of the Neo-Tethys / Geological Society, London, Special Publications, 17:301-317, doi:10.1144/GSL.SP.1984.017.01.22 --- Ingrid Reuber: Mylonitic ductile shear zones within tectonites and cumulates as evidence for an oceanic transform fault in the Antalya ophiolite, S.W. Turkey / Geological Society, London, Special Publications, 17:319-334, doi:10.1144/GSL.SP.1984.017.01.23 --- Pınar O. Yılmaz: Fossil and K-Ar data for the age of the Antalya complex, S W Turkey / Geological Society, London, Special Publications, 17:335-347, doi:10.1144/GSL.SP.1984.017.01.24 --- L. E. Ricou, J. Marcoux, and H. Whitechurch: The Mesozoic organization of the Taurides: one or several ocean basins? / Geological Society, London, Special Publications, 17:349-359, doi:10.1144/GSL.SP.1984.017.01.25 --- A. Michard, H. Whitechurch, L. E. Ricou, R. Montigny, and E. Yazgan: Tauric subduction (Malatya-Elazıǧ provinces) and its bearing on tectonics of the Tethyan realm in Turkey / Geological Society, London, Special Publications, 17:361-373, doi:10.1144/GSL.SP.1984.017.01.26 --- G. Aktaş and A. H. F. Robertson: The Maden Complex, SE Turkey: evolution of a Neotethyan active margin / Geological Society, London, Special Publications, 17:375-402, doi:10.1144/GSL.SP.1984.017.01.27 --- Cahit Helvaci and William L. Griffin: Rb-Sr geochronology of the Bitlis Massif, Avnik (Bingöl) area, S.E. Turkey / Geological Society, London, Special Publications, 17:403-413, doi:10.1144/GSL.SP.1984.017.01.28 --- Ömer T. Akıncı: The Eastern Pontide volcano-sedimentary belt and associated massive sulphide deposits / Geological Society, London, Special Publications, 17:415-428, doi:10.1144/GSL.SP.1984.017.01.29 --- A. I. Okay and N. Özgül: HP/LT metamorphism and the structure of the Alanya Massif, Southern Turkey: an allochthonous composite tectonic sheet / Geological Society, London, Special Publications, 17:429-439, doi:10.1144/GSL.SP.1984.017.01.30 --- Teoman N. Norman: The role of the Ankara Melange in the development of Anatolia (Turkey) / Geological Society, London, Special Publications, 17:441-447, doi:10.1144/GSL.SP.1984.017.01.31 --- Ayla Tankut: Basic and ultrabasic rocks from the Ankara Melange, Turkey / Geological Society, London, Special Publications, 17:449-454, doi:10.1144/GSL.SP.1984.017.01.32 --- A. I. Okay: Distribution and characteristics of the north-west Turkish blueschists / Geological Society, London, Special Publications, 17:455-466, doi:10.1144/GSL.SP.1984.017.01.33 --- N. Görür, F.Y. Oktay, İ. Seymen, and A. M. C. Şengör: Palaeotectonic evolution of the Tuzgölü basin complex, Central Turkey: sedimentary record of a Neo-Tethyan closure / Geological Society, London, Special Publications, 17:467-482, doi:10.1144/GSL.SP.1984.017.01.34 --- J. P. Lauer: Geodynamic evolution of Turkey and Cyprus based on palaeomagnetic data / Geological Society, London, Special Publications, 17:483-491, doi:10.1144/GSL.SP.1984.017.01.35 --- 4. Neotethys: Greece and the Balkans --- Editor’s introduction / Geological Society, London, Special Publications, 17:493-498, doi:10.1144/GSL.SP.1984.017.01.36 --- Robert Hall, M. G. Audley-Charles, and D. J. Carter: The significance of Crete for the evolution of the Eastern Mediterranean / Geological Society, London, Special Publications, 17:499-516, doi:10.1144/GSL.SP.1984.017.01.37 --- Michel Bonneau: Correlation of the Hellenide nappes in the south-east Aegean and their tectonic reconstruction / Geological Society, London, Special Publications, 17:517-527, doi:10.1144/GSL.SP.1984.017.01.38 --- M. Okrusch, P. Richter
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  • 3
    Description / Table of Contents: The Eastern Mediterranean region is a classic area for the study of tectonic processes and settings related to the development of the Tethyan orogenic belt. The present set of research and synthesis papers by Earth scientist from countries in this region and others provides an up-to-date, interdisciplinary overview of the tectonic development of the Eastern Mediterrenean region from Precambrian to Recent. Key topics include continental rifting, ophiolite genesis and emplacement, continental collision, extensional tectonics, crustal exhumation and intraplate deformation (e.g. active faulting). Alternative tectonic reconstructions of the Tethyan orogen are presented and discussed, with important implications for other regions of the world. The book will be an essential source of information and interpretation for academic researchers (geologists and geophysicists), advanced undergraduates and also for industry professionals, including those concerned with hydrocarbons, minerals and geological hazards (e.g. earthquakes).
    Pages: Online-Ressource (717 Seiten)
    ISBN: 9781862391987
    Language: English
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  • 4
    Description / Table of Contents: Anatolia and the easternmost Mediterranean region, especially Turkey, Cyprus and northern Syria, represent an excellent natural laboratory for the study of fundamental geological processes (e.g. rifting, seafloor spreading, ophiolite genesis and emplacement, subduction, exhumation and collision). Their interaction has created an intriguing array of deep-sea basins, microcontinents and suture zones. The volume's 22 papers include a large amount of new field-based information (much of it multidisciplinary and the product of teamwork). After an overview, the volume is divided into four sections: Late Palaeozoic–Early Cenozoic of the Pontides (northern Turkey); Late Palaeozoic–Early Cenozoic of the Taurides–Anatolides (central and southern Turkey); Late Cretaceous–Pliocene sedimentary basins and structural development (central Anatolia to the Mediterranean); Late Miocene–Recent Neotectonics (southern Turkey, Cyprus and northern Syria). The volume will interest numerous academic researchers, those concerned with resources (e.g. hydrocarbons; mineral deposits) and also hazards (e.g. earthquakes), as well as advanced undergraduate and postgraduate students.
    Pages: Online-Ressource (VI, 649 Seiten)
    ISBN: 9781862393530
    Language: English
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  • 5
    Publication Date: 2018
    Description: 〈p〉We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer types from The Cancer Genome Atlas (TCGA). We identify 562,709 transposase-accessible DNA elements that substantially extend the compendium of known cis-regulatory elements. Integration of ATAC-seq (the assay for transposase-accessible chromatin using sequencing) with TCGA multi-omic data identifies a large number of putative distal enhancers that distinguish molecular subtypes of cancers, uncovers specific driving transcription factors via protein-DNA footprints, and nominates long-range gene-regulatory interactions in cancer. These data reveal genetic risk loci of cancer predisposition as active DNA regulatory elements in cancer, identify gene-regulatory interactions underlying cancer immune evasion, and pinpoint noncoding mutations that drive enhancer activation and may affect patient survival. These results suggest a systematic approach to understanding the noncoding genome in cancer to advance diagnosis and therapy.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2018-09-06
    Description: Neutrophils are the first immune cells recruited to a site of injury or infection, where they perform many functions. Having completed their role, neutrophils must be removed from the inflammatory site—either by apoptosis and efferocytosis or by reverse migration away from the wound—for restoration of normal tissue homeostasis. Disruption of these tightly controlled physiological processes of neutrophil removal can lead to a range of inflammatory diseases. We used an in vivo zebrafish model to understand the role of lipid mediator production in neutrophil removal. Following tailfin amputation in the absence of macrophages, neutrophillic inflammation does not resolve, due to loss of macrophage-dependent handling of eicosanoid prostaglandin E2 (PGE 2 ) that drives neutrophil removal via promotion of reverse migration. Knockdown of endogenous PGE synthase gene reveals PGE 2 as essential for neutrophil inflammation resolution. Furthermore, PGE 2 is able to signal through EP4 receptors during injury, causing an increase in Alox12 production and switching toward anti-inflammatory eicosanoid signaling. Our data confirm regulation of neutrophil migration by PGE 2 and LXA 4 (lipoxin A 4 ) in an in vivo model of inflammation resolution. This pathway may contain therapeutic targets for driving inflammation resolution in chronic inflammatory disease.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 7
    Publication Date: 2018-10-26
    Description: We present the genome-wide chromatin accessibility profiles of 410 tumor samples spanning 23 cancer types from The Cancer Genome Atlas (TCGA). We identify 562,709 transposase-accessible DNA elements that substantially extend the compendium of known cis-regulatory elements. Integration of ATAC-seq (the assay for transposase-accessible chromatin using sequencing) with TCGA multi-omic data identifies a large number of putative distal enhancers that distinguish molecular subtypes of cancers, uncovers specific driving transcription factors via protein-DNA footprints, and nominates long-range gene-regulatory interactions in cancer. These data reveal genetic risk loci of cancer predisposition as active DNA regulatory elements in cancer, identify gene-regulatory interactions underlying cancer immune evasion, and pinpoint noncoding mutations that drive enhancer activation and may affect patient survival. These results suggest a systematic approach to understanding the noncoding genome in cancer to advance diagnosis and therapy.
    Keywords: Medicine, Diseases, Online Only
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2013-05-04
    Description: New age data from Sr isotope analysis and both planktonic foraminifera and nannofossils are presented and discussed here for the Upper Eocene–Upper Miocene sedimentary rocks of the Degirmenlik (Kythrea) Group. New dating is also given of some Cretaceous and Pliocene sediments. In a revised stratigraphy the Degirmenlik (Kythrea) Group is divided into ten formations. Different Upper Miocene formations are developed to the north and south of a regionally important, E–W-trending syn-sedimentary fault. The samples were dated wherever possible by three independent methods, namely utilizing Sr isotopes, calcareous nannofossils and planktonic foraminifera. Some of the Sr isotopic dates are incompatible with the nannofossil and/or the planktonic foraminiferal dates. This is mainly due to reworking within gravity-deposited or current-affected sediments. When combined, the reliable age data allow an overall biostratigraphy and chronology to be erected. Several of the boundaries of previously defined formations are revised. Sr data that are incompatible with well-constrained biostratigraphical ages are commonly of Early Miocene age. This is attributed to a regional uplift event located to the east of Cyprus, specifically the collision of the Anatolian (Eurasian) and Arabian (African) plates during Early Miocene time. This study, therefore, demonstrates that analytically sound Sr isotopic ages can yield geologically misleading ages, particularly where extensive sediment reworking has occurred. Convincing ages are obtained when isotopic dating is combined with as many forms of biostratigraphical dating as possible, and this may also reveal previously unsuspected geological events (e.g. tectonic uplift or current activity).
    Print ISSN: 0016-7568
    Electronic ISSN: 1469-5081
    Topics: Geosciences
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Vacuum 35 (1985), S. 63 
    ISSN: 0042-207X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
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  • 10
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    In:  Geophys. Res. Lett., Amsterdam, Schweizerbart'sche Verlagsbuchhandlung, vol. 25, no. 18, pp. 3409-3412, pp. L07302, (ISSN 0016-8548, ISBN 3-510-50045-8)
    Publication Date: 1998
    Keywords: Crustal deformation (cf. Earthquake precursor: deformation or strain) ; Volcanology ; Geodesy ; GRL
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