Publication Date:
1983-09-23
Description:
The lung colonization of B16-F1 cells grown in flat and spherical configurations was studied. Cells cultivated in vitro as spheroids on a nonadhesive substrate expressed in a reversible fashion a marked increase in their propensity to establish metastases. The altered metastatic capability was accompanied by a reversible reduction in the accessibility of cell surface proteins to external iodination and by a dramatic decrease in the synthesis of vimentin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raz, A -- Ben-Ze'ev, A -- New York, N.Y. -- Science. 1983 Sep 23;221(4617):1307-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612347" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Adhesion
;
Cell Division
;
Cells, Cultured
;
Intermediate Filament Proteins/biosynthesis
;
Lung Neoplasms/secondary
;
Melanoma/*pathology
;
Membrane Proteins/physiology
;
Mice
;
*Neoplasm Metastasis
;
Neoplasm Proteins/physiology
;
Neoplasms, Experimental/pathology
;
Vimentin
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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