Publication Date:
2014-09-25
Description:
Article Mutations in PIK3CA , a catalytic subunit of PI3 kinase, are linked to deregulation of Akt-mTOR signalling in many cancers. Here, using a SILAC-based quantitative proteomic approach, the authors discover six new AKT1 substrates, including the actin regulator cortactin. Nature Communications doi: 10.1038/ncomms5961 Authors: Xinyan Wu, Santosh Renuse, Nandini A. Sahasrabuddhe, Muhammad Saddiq Zahari, Raghothama Chaerkady, Min-Sik Kim, Raja S. Nirujogi, Morassa Mohseni, Praveen Kumar, Rajesh Raju, Jun Zhong, Jian Yang, Johnathan Neiswinger, Jun-Seop Jeong, Robert Newman, Maureen A. Powers, Babu Lal Somani, Edward Gabrielson, Saraswati Sukumar, Vered Stearns, Jiang Qian, Heng Zhu, Bert Vogelstein, Ben Ho Park, Akhilesh Pandey
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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