Publication Date:
2011-08-27
Description:
Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group to the Neandertals. Virtual genotyping of Denisovan and Neandertal genomes identified archaic HLA haplotypes carrying functionally distinctive alleles that have introgressed into modern Eurasian and Oceanian populations. These alleles, of which several encode unique or strong ligands for natural killer cell receptors, now represent more than half the HLA alleles of modern Eurasians and also appear to have been later introduced into Africans. Thus, adaptive introgression of archaic alleles has significantly shaped modern human immune systems.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677943/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677943/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abi-Rached, Laurent -- Jobin, Matthew J -- Kulkarni, Subhash -- McWhinnie, Alasdair -- Dalva, Klara -- Gragert, Loren -- Babrzadeh, Farbod -- Gharizadeh, Baback -- Luo, Ma -- Plummer, Francis A -- Kimani, Joshua -- Carrington, Mary -- Middleton, Derek -- Rajalingam, Raja -- Beksac, Meral -- Marsh, Steven G E -- Maiers, Martin -- Guethlein, Lisbeth A -- Tavoularis, Sofia -- Little, Ann-Margaret -- Green, Richard E -- Norman, Paul J -- Parham, Peter -- AI031168/AI/NIAID NIH HHS/ -- HHSN261200800001E/PHS HHS/ -- R01 AI031168/AI/NIAID NIH HHS/ -- RR000165/RR/NCRR NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2011 Oct 7;334(6052):89-94. doi: 10.1126/science.1209202. Epub 2011 Aug 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21868630" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Biological
;
African Continental Ancestry Group/genetics
;
Alleles
;
Animals
;
Asian Continental Ancestry Group/genetics
;
Continental Population Groups/*genetics
;
European Continental Ancestry Group/genetics
;
Evolution, Molecular
;
*Genes, MHC Class I
;
Genetic Variation
;
HLA-A Antigens/*genetics/immunology/metabolism
;
HLA-B Antigens/*genetics/immunology/metabolism
;
HLA-C Antigens/*genetics/immunology
;
Haplotypes
;
Hominidae/*genetics/*immunology
;
Humans
;
*Hybridization, Genetic
;
Killer Cells, Natural/immunology
;
Ligands
;
Linkage Disequilibrium
;
Molecular Sequence Data
;
Oceanic Ancestry Group/genetics
;
Receptors, KIR/immunology/metabolism
;
Selection, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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