Publication Date:
1986-02-14
Description:
While assessing a potential role of adrenal glands in the production of the hitherto unidentified puberty-delaying pheromone of female mice, the urinary volatile profiles of normal and adrenalectomized animals were quantitatively compared. Six components, whose concentrations were depressed after adrenalectomy, were identified: 2-heptanone, trans-5-hepten-2-one, trans-4-hepten-2-one, n-pentyl acetate, cis-2-penten-1-yl acetate, and 2,5-dimethylpyrazine. When these laboratory-synthesized chemicals were added (in their natural concentrations) to either previously inactive urine from adrenalectomized females or plain water, the biological activity was fully restored.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Novotny, M -- Jemiolo, B -- Harvey, S -- Wiesler, D -- Marchlewska-Koj, A -- New York, N.Y. -- Science. 1986 Feb 14;231(4739):722-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945805" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenal Glands/*physiology
;
Animals
;
Female
;
Ketones/urine
;
Mice
;
Ovary/physiology
;
Pentanols/urine
;
Pheromones/physiology/urine
;
Pyrazines/urine
;
*Sexual Maturation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
