Publication Date:
1978-05-19
Description:
Insulin labeled with iodine-125 binds to receptors on isolated rat hepatocytes. At low temperatures initial binding is restricted to the plasma membrane as detected by direct quantitative autoradiographic analysis with the electron microscope. With increasing time and temperature of incubation there is a systematic and progressive translocation of autoradiographic grains to a highly limited area of the cell periphery representing no more than 15% of the radius of the cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorden, P -- Carpentier, J L -- Freychet, P -- LeCam, A -- Orci, L -- New York, N.Y. -- Science. 1978 May 19;200(4343):782-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644321" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Membrane/metabolism
;
Endocytosis
;
Insulin/*metabolism
;
Kinetics
;
Liver/*metabolism/ultrastructure
;
Lymphocytes/metabolism
;
Lysosomes/metabolism
;
Molecular Weight
;
Rats
;
Receptor, Insulin/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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