Publication Date:
2000-08-05
Description:
Autosomal dominant progressive external ophthalmoplegia is a rare human disease that shows a Mendelian inheritance pattern, but is characterized by large-scale mitochondrial DNA (mtDNA) deletions. We have identified two heterozygous missense mutations in the nuclear gene encoding the heart/skeletal muscle isoform of the adenine nucleotide translocator (ANT1) in five families and one sporadic patient. The familial mutation substitutes a proline for a highly conserved alanine at position 114 in the ANT1 protein. The analogous mutation in yeast caused a respiratory defect. These results indicate that ANT has a role in mtDNA maintenance and that a mitochondrial disease can be caused by a dominant mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaukonen, J -- Juselius, J K -- Tiranti, V -- Kyttala, A -- Zeviani, M -- Comi, G P -- Keranen, S -- Peltonen, L -- Suomalainen, A -- 1180/Telethon/Italy -- New York, N.Y. -- Science. 2000 Aug 4;289(5480):782-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Public Health Institute, Department of Human Molecular Genetics, Mannerheimintie 166, 00300 Helsinki, Finland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10926541" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Amino Acid Substitution
;
Animals
;
DNA, Mitochondrial/*genetics/*metabolism
;
Female
;
Founder Effect
;
Genes, Dominant
;
Humans
;
Isoenzymes/chemistry/genetics/metabolism
;
Italy
;
Male
;
Mitochondrial ADP, ATP Translocases/chemistry/*genetics/*metabolism
;
Molecular Sequence Data
;
Mutation, Missense
;
Ophthalmoplegia, Chronic Progressive External/enzymology/*genetics
;
Oxygen Consumption
;
Pedigree
;
Point Mutation
;
Saccharomyces cerevisiae/enzymology/genetics/metabolism
;
Sequence Deletion
;
Transformation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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