Publication Date:
1999-09-11
Description:
In congenitally deaf cats, the central auditory system is deprived of acoustic input because of degeneration of the organ of Corti before the onset of hearing. Primary auditory afferents survive and can be stimulated electrically. By means of an intracochlear implant and an accompanying sound processor, congenitally deaf kittens were exposed to sounds and conditioned to respond to tones. After months of exposure to meaningful stimuli, the cortical activity in chronically implanted cats produced field potentials of higher amplitudes, expanded in area, developed long latency responses indicative of intracortical information processing, and showed more synaptic efficacy than in naive, unstimulated deaf cats. The activity established by auditory experience resembles activity in hearing animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klinke, R -- Kral, A -- Heid, S -- Tillein, J -- Hartmann, R -- New York, N.Y. -- Science. 1999 Sep 10;285(5434):1729-33.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physiologisches Institut III, Theodor-Stern-Kai 7, D-60590 Frankfurt/M, Germany. klinke@em.uni-frankfurt.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10481008" target="_blank"〉PubMed〈/a〉
Keywords:
Acoustic Stimulation
;
Animals
;
Auditory Cortex/*physiology
;
Auditory Pathways/*physiology
;
Cats
;
Cochlea/*physiology
;
*Cochlear Implants
;
Conditioning (Psychology)
;
Deafness/congenital/*physiopathology/therapy
;
Electric Stimulation
;
Evoked Potentials, Auditory
;
Hearing
;
Synapses/physiology
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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