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  • 1
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    SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-03-06
    Description: Sirtuins are NAD(+)-dependent protein deacetylases. They mediate adaptive responses to a variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2 (refs 1, 2). Mice lacking both Sirt3 alleles appear phenotypically normal under basal conditions, but show marked hyperacetylation of several mitochondrial proteins. Here we report that SIRT3 expression is upregulated during fasting in liver and brown adipose tissues. During fasting, livers from mice lacking SIRT3 had higher levels of fatty-acid oxidation intermediate products and triglycerides, associated with decreased levels of fatty-acid oxidation, compared to livers from wild-type mice. Mass spectrometry of mitochondrial proteins shows that long-chain acyl coenzyme A dehydrogenase (LCAD) is hyperacetylated at lysine 42 in the absence of SIRT3. LCAD is deacetylated in wild-type mice under fasted conditions and by SIRT3 in vitro and in vivo; and hyperacetylation of LCAD reduces its enzymatic activity. Mice lacking SIRT3 exhibit hallmarks of fatty-acid oxidation disorders during fasting, including reduced ATP levels and intolerance to cold exposure. These findings identify acetylation as a novel regulatory mechanism for mitochondrial fatty-acid oxidation and demonstrate that SIRT3 modulates mitochondrial intermediary metabolism and fatty-acid use during fasting.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841477/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841477/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirschey, Matthew D -- Shimazu, Tadahiro -- Goetzman, Eric -- Jing, Enxuan -- Schwer, Bjoern -- Lombard, David B -- Grueter, Carrie A -- Harris, Charles -- Biddinger, Sudha -- Ilkayeva, Olga R -- Stevens, Robert D -- Li, Yu -- Saha, Asish K -- Ruderman, Neil B -- Bain, James R -- Newgard, Christopher B -- Farese, Robert V Jr -- Alt, Frederick W -- Kahn, C Ronald -- Verdin, Eric -- DK019514-29/DK/NIDDK NIH HHS/ -- DK59637/DK/NIDDK NIH HHS/ -- K01 DK076573/DK/NIDDK NIH HHS/ -- K08 AG022325/AG/NIA NIH HHS/ -- K08 AG022325-01A1/AG/NIA NIH HHS/ -- P01 HL068758/HL/NHLBI NIH HHS/ -- P01 HL068758-06A1/HL/NHLBI NIH HHS/ -- P30 DK026743/DK/NIDDK NIH HHS/ -- P30 DK026743-26A1/DK/NIDDK NIH HHS/ -- R01 DK019514/DK/NIDDK NIH HHS/ -- R01 DK019514-29/DK/NIDDK NIH HHS/ -- R01 DK067509/DK/NIDDK NIH HHS/ -- R01 DK067509-04/DK/NIDDK NIH HHS/ -- U24 DK059637/DK/NIDDK NIH HHS/ -- U24 DK059637-01/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Mar 4;464(7285):121-5. doi: 10.1038/nature08778.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20203611" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Acyl-CoA Dehydrogenase, Long-Chain/chemistry/*metabolism ; Adenosine Triphosphate/biosynthesis/metabolism ; Adipose Tissue, Brown/enzymology/metabolism ; Animals ; Body Temperature Regulation ; Caloric Restriction ; Carnitine/analogs & derivatives/metabolism ; Cell Line ; Cold Temperature ; Fasting/metabolism ; Fatty Acids/*metabolism ; Humans ; Hypoglycemia/metabolism ; Liver/enzymology/metabolism ; Male ; Mass Spectrometry ; Mice ; Mitochondria/*enzymology/*metabolism ; Oxidation-Reduction ; Sirtuin 3/deficiency/genetics/*metabolism ; Triglycerides/metabolism ; Up-Regulation
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Experimental investigation of T=1 analog states of ^{26} Al and ^{26} Mg (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-04-02
    Description: Author(s): Vishal Srivastava, C. Bhattacharya, T. K. Rana, S. Manna, S. Kundu, S. Bhattacharya, K. Banerjee, P. Roy, R. Pandey, G. Mukherjee, T. K. Ghosh, J. K. Meena, T. Roy, A. Chaudhuri, M. Sinha, A. K. Saha, Md. A. Asgar, A. Dey, Subinit Roy, and Md. M. Shaikh The even-even nucleus Mg 26 has been studied through the reaction Al 27 ( d , He 3 ) at 25 MeV beam energy. The spectroscopic factors of the lowest ( T = 1 ) states of Mg 26 have been extracted using the zero-range distorted wave Born approximation. These spectroscopic factors are compared with those of T = 1 anal… [Phys. Rev. C 93, 044601] Published Fri Apr 01, 2016
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Eastern Indian 3800-million-year-old crust and early mantle differentiation (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-26
    Description: Samarium-neodymium data for nine granitic and tonalite gneisses occurring as remnants within the Singhbhum granite batholith in eastern India define an isochron of age 3775 +/- 89 x 10(6) years with an initial (143)Nd/(144)Nd ratio of 0.50798 +/- 0.00007. This age contrasts with the rubidium-strontium age of 3200 x 10(6) years for the same suite of rocks. On the basis of the new samarium-neodynium data, field data, and petrologic data, a scheme of evolution is proposed for the Archean crust in eastern India. The isotopic data provide evidence that parts of the earth's mantle were already differentiated with respect to the chondritic samarium-neodymium ratio 3800 x l0(6) years ago.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Basu, A R -- Ray, S L -- Saha, A K -- Sarkar, S N -- New York, N.Y. -- Science. 1981 Jun 26;212(4502):1502-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17790540" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Excitation energy dependence of the level density parameter close to the doubly magic ^{208} Pb (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-12-13
    Description: Author(s): Pratap Roy, K. Banerjee, C. Bhattacharya, R. Pandey, A. Sen, S. Manna, S. Kundu, T. K. Rana, T. K. Ghosh, G. Mukherjee, T. Roy, A. Dhal, A. Dey, J. K. Meena, A. K. Saha, Deepak Pandit, S. Mukhopadhyay, and S. Bhattacharya Neutron evaporation spectra have been measured from He 4 + Pb 208 and He 4 + Bi 209 reactions by using He 4 -ion beams of several bombarding energies. Excitation-energy dependence of the level density parameter has been studied for the two systems in the excitation energy range of ∼ 18 –50 MeV. For both the rea… [Phys. Rev. C 94, 064607] Published Mon Dec 12, 2016
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    Estimation of direct components of the decay of the Hoyle state (2013)
    American Physical Society (APS)
    Details
    Publication Date: 2013-08-15
    Description: Author(s): T. K. Rana, S. Bhattacharya, C. Bhattacharya, S. Kundu, K. Banerjee, T. K. Ghosh, G. Mukherjee, R. Pandey, P. Roy, V. Srivastava, M. Gohil, J. K. Meena, H. Pai, A. K. Saha, J. K. Sahoo, and R. M. Saha A high-statistics, high-resolution, complete kinematical measurement has been performed to estimate the quantitative contributions of various direct 3 α decay mechanisms in the decay of the famous Hoyle state, the 0 2 + resonant excited state of 12 C at an excitation energy of 7.654 MeV, using inelastic... [Phys. Rev. C 88, 021601] Published Wed Aug 14, 2013
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
    Electronic Resource
    Electronic Resource
    Evaluation of Chuni, a commercially available low-cost cattle fodder, in the diet for rohu, Labeo rohita (Hamilton), fingerlings (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Aquaculture research 29 (1998), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: An 80-day feeding experiment was conducted to evaluate the suitability of incorporation of Chuni, a commercially available low-cost cattle fodder, comprising cereal grains and leguminous seeds, into the practical diets for rohu, Labeo rohita (Hamilton), an Indian major carp, fingerlings (average weight= 6.23 0.15g). Four experimental diets, incorporating Chuni at levels of 10%, 20%, 30% and 40% into a fish-meal-based control diet (35% protein) were formulated. In terms of fish growth, feed conversion, protein efficiency ratio, apparent nutrient digestibility, and protein and lipid deposition in fish muscle, 10%Chuni incorporated diet showed the best performance of fish and was comparable to those with the control diet. However, the growth of fish was lower with higher levels of Chuni incorporation (20% or more), which resulted in poor nutrient digestibility. The present results indicate that Chuni could be used as a component in the supplementary diet for L. rohita fingerlings, partially substituting the fish-meal-based diet up to the extent of 10%, and it this is the first report on the use of Chuni as a dietary ingredient in diets for carp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2109.1998.29100761.x
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  • 7
    Electronic Resource
    Electronic Resource
    Rotundifoline, an Oxoindole Alkaloid (1998)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 399-401 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270197013528
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  • 8
    Electronic Resource
    Electronic Resource
    Potassium–Argon Ages from the Oldest Metamorphic Belt in India (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 946-948 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The area of fifty square miles to the west arid south of Champua (22 04': 85 40') (Fig. 1) constitutes the type area of the Older Metamorphic Series; there the series is extensively injected and replaced by granite and pegmatite4'8. In an attempt to establish the stratigraphic status of the Older ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/215946a0
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  • 9
    Electronic Resource
    Electronic Resource
    Pattern formation and morphogenesis: A reaction-diffusion model (1986)
    Springer
    Bulletin of mathematical biology 48 (1986), S. 213-228 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The problem of cellular differentiation and consequent pattern generation during embryonic development has been mathematically investigated with the help of a reaction-diffusion model. It is by now a well-recognized fact that diffusion of micromolecules (through intercellular gap junctions), which is dependent on the spatial parameter (r), serve the purpose of ‘positional information’ for differentiation. Based on this principle the present model has been constructed by coupling the Goodwin-type equations for RNA and protein synthesis with the diffusion process. The homogeneous Goodwin system can exhibit stable periodic solution if the value of the cooperativity as measured by the Hill coefficient (ρ) is greater than 8, which is not biologically realistic. In the present work it has been observed that inclusion of a negative cross-diffusion can drive the system into local instability for any value of ρ and thus a time-periodic spatial solution is possible around the unstable local equilibrium, eventually leading to a definite pattern formation. Inclusion of a negative cross-diffusion thus makes the system biologically realistic. The cross-diffusion can also give rise to a stationary wave-like dissipative structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02460024
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  • 10
    Electronic Resource
    Electronic Resource
    Nuclear Energetics and β-Activity (1946)
    [s.l.] : Nature Publishing Group
    Nature 158 (1946), S. 6-9 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] EVER since the discovery by Joliot and Curie of the phenomenon of induced radioactivity in 1934, a very large number of radioactive nuclei, exceeding 450, has been prepared in the laboratory. In recent years, new types of radioactive nuclei have been obtained from fission of heavy nuclei like 92U, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/158006a0
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