Publication Date:
1980-10-03
Description:
Clonal lines of Rauscher erythroleukemia cells exhibited selective responses to two inducers of differentiation, erythropoietin and dimethyl sulfoxide. There were substantial quantitiative differences between clones that reponded to both inducers. Several clones differentiated only in response to erythropoietin. Erythropoietin stimulated cell proliferation and differentiation whereas dimethyl sulfoxide inhibited proliferation, suggesting dissimilar modes of action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sytkowski, A J -- Salvado, A J -- Smith, G M -- McIntyre, C J -- deBoth, N J -- CA-18662/CA/NCI NIH HHS/ -- CA-26105/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):74-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6932101" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation/*drug effects
;
Cell Division/drug effects
;
Clone Cells/drug effects
;
Dimethyl Sulfoxide/*pharmacology
;
Erythropoietin/*pharmacology
;
Hemoglobins/biosynthesis
;
Leukemia, Erythroblastic, Acute/*pathology
;
Leukemia, Experimental/pathology
;
Mice
;
Rauscher Virus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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