Publication Date:
2004-08-03
Description:
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bruggemann, Holger -- Henne, Anke -- Hoster, Frank -- Liesegang, Heiko -- Wiezer, Arnim -- Strittmatter, Axel -- Hujer, Sandra -- Durre, Peter -- Gottschalk, Gerhard -- New York, N.Y. -- Science. 2004 Jul 30;305(5684):671-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gottingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Gottingen, Grisebachstrasse 8, 37077 Gottingen, Germany. hbruegg@pasteur.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15286373" target="_blank"〉PubMed〈/a〉
Keywords:
Acne Vulgaris/immunology/microbiology
;
Amino Acid Motifs
;
Amino Acid Sequence
;
Antigens, Bacterial/chemistry/genetics
;
Bacterial Proteins/chemistry/genetics/immunology
;
Base Sequence
;
Chromosomes, Bacterial/genetics
;
Computational Biology
;
Energy Metabolism
;
Esterases/genetics/metabolism
;
Genes, Bacterial
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*Genome, Bacterial
;
Heat-Shock Proteins/chemistry/genetics
;
Humans
;
Hydrolases/genetics/metabolism
;
Lipase/genetics/metabolism
;
Molecular Sequence Data
;
Oxidative Phosphorylation
;
Propionibacterium acnes/*genetics/immunology/physiology
;
*Sequence Analysis, DNA
;
Skin/*microbiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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