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  • 1
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    Alteration of the phase and period of a circadian oscillator by a reversible transcription inhibitor (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-08-09
    Description: A function for transcription in the mechanism of a circadian oscillator was investigated with the reversible transcription inhibitor 5,6-dichloro-1-beta-D- ribobenzimidazole (DRB). Two-hour treatments with DRB shifted the phase of the circadian rhythm of the isolated eye of Aplysia, and continuous treatments of DRB lengthened the free running period of this rhythm. Camptothecin, an inhibitor of transcription that is structurally unrelated to DRB, had similar effects on the circadian rhythm. These results suggest that transcription may be part of the circadian oscillating mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raju, U -- Koumenis, C -- Nunez-Regueiro, M -- Eskin, A -- MH41979/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1991 Aug 9;253(5020):673-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemical and Biophysical Sciences, University of Houston, TX 77204-5934.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1871602" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia ; Camptothecin/*pharmacology ; Circadian Rhythm/*radiation effects ; Dichlororibofuranosylbenzimidazole/*pharmacology ; Eye/drug effects ; In Vitro Techniques ; *Ocular Physiological Phenomena ; Time Factors ; Transcription, Genetic/*drug effects ; Uridine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Role of transforming growth factor-beta in long-term synaptic facilitation in Aplysia (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-02-28
    Description: The role of transforming growth factor-beta (TGF-beta) in long-term synaptic facilitation was examined in isolated Aplysia ganglia. Treatment with TGF-beta1 induced long-term facilitation (24 and 48 hours), but not short-term (5 to 15 minutes) or intermediate-term (2 to 4 hours) facilitation. The long-term effects of TGF-beta1 were not additive with those of serotonin. Moreover, serotonin-induced facilitation was blocked by an inhibitor of TGF-beta. Thus, activation of TGF-beta may be part of the cascade of events underlying long-term sensitization, consistent with the hypothesis that signaling molecules that participate in development also have roles in adult neuronal plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, F -- Endo, S -- Cleary, L J -- Eskin, A -- Byrne, J H -- K05 MH-00649/MH/NIMH NIH HHS/ -- R01-NS-19895/NS/NINDS NIH HHS/ -- R01-NS-28462/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1997 Feb 28;275(5304):1318-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9036859" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia/*physiology ; Electric Stimulation ; Motor Neurons/physiology ; *Neuronal Plasticity ; Neurons, Afferent/physiology ; Protein-Serine-Threonine Kinases ; Receptors, Transforming Growth Factor beta/physiology ; Serotonin/pharmacology ; Signal Transduction ; Synapses/drug effects/*physiology ; *Synaptic Transmission/drug effects ; Transforming Growth Factor beta/*pharmacology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-12-07
    Description: Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are not understood. Single-cell analyses of patient-derived models and clinical samples from glioblastoma patients treated with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) demonstrate that tumor cells reversibly up-regulate or suppress mutant EGFR expression, conferring distinct cellular phenotypes to reach an optimal equilibrium for growth. Resistance to EGFR TKIs is shown to occur by elimination of mutant EGFR from extrachromosomal DNA. After drug withdrawal, reemergence of clonal EGFR mutations on extrachromosomal DNA follows. These results indicate a highly specific, dynamic, and adaptive route by which cancers can evade therapies that target oncogenes maintained on extrachromosomal DNA.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049335/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049335/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathanson, David A -- Gini, Beatrice -- Mottahedeh, Jack -- Visnyei, Koppany -- Koga, Tomoyuki -- Gomez, German -- Eskin, Ascia -- Hwang, Kiwook -- Wang, Jun -- Masui, Kenta -- Paucar, Andres -- Yang, Huijun -- Ohashi, Minori -- Zhu, Shaojun -- Wykosky, Jill -- Reed, Rachel -- Nelson, Stanley F -- Cloughesy, Timothy F -- James, C David -- Rao, P Nagesh -- Kornblum, Harley I -- Heath, James R -- Cavenee, Webster K -- Furnari, Frank B -- Mischel, Paul S -- NS73831/NS/NINDS NIH HHS/ -- P01 CA095616/CA/NCI NIH HHS/ -- P01-CA95616/CA/NCI NIH HHS/ -- P30 CA023100/CA/NCI NIH HHS/ -- R01 NS052563/NS/NINDS NIH HHS/ -- R01 NS073831/NS/NINDS NIH HHS/ -- R01 NS080939/NS/NINDS NIH HHS/ -- R01-NS080939/NS/NINDS NIH HHS/ -- T32 CA009056/CA/NCI NIH HHS/ -- U54 CA151819/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 3;343(6166):72-6. doi: 10.1126/science.1241328. Epub 2013 Dec 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24310612" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents/*therapeutic use ; Central Nervous System Neoplasms/*drug therapy/genetics ; DNA/genetics ; Drug Resistance, Neoplasm/*genetics ; Erlotinib Hydrochloride ; Glioblastoma/*drug therapy/genetics ; Humans ; Mice ; *Molecular Targeted Therapy ; Mutation ; Neoplasm Transplantation ; Protein Kinase Inhibitors/*therapeutic use ; Quinazolines/therapeutic use ; Receptor, Epidermal Growth Factor/antagonists & inhibitors/*genetics ; Single-Cell Analysis ; Tumor Cells, Cultured ; Withholding Treatment
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Accelerated actin filament polymerization from microtubule plus ends (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-05-21
    Description: Microtubules (MTs) govern actin network remodeling in a wide range of biological processes, yet the mechanisms underlying this cytoskeletal cross-talk have remained obscure. We used single-molecule fluorescence microscopy to show that the MT plus-end-associated protein CLIP-170 binds tightly to formins to accelerate actin filament elongation. Furthermore, we observed mDia1 dimers and CLIP-170 dimers cotracking growing filament ends for several minutes. CLIP-170-mDia1 complexes promoted actin polymerization ~18 times faster than free-barbed-end growth while simultaneously enhancing protection from capping proteins. We used a MT-actin dynamics co-reconstitution system to observe CLIP-170-mDia1 complexes being recruited to growing MT ends by EB1. The complexes triggered rapid growth of actin filaments that remained attached to the MT surface. These activities of CLIP-170 were required in primary neurons for normal dendritic morphology. Thus, our results reveal a cellular mechanism whereby growing MT plus ends direct rapid actin assembly.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henty-Ridilla, Jessica L -- Rankova, Aneliya -- Eskin, Julian A -- Kenny, Katelyn -- Goode, Bruce L -- GM083137/GM/NIGMS NIH HHS/ -- T32NS007292/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2016 May 20;352(6288):1004-9. doi: 10.1126/science.aaf1709.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA. ; Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA. goode@brandeis.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27199431" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Adenylate cyclase activation shifts the phase of a circadian pacemaker (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-04-01
    Description: Forskolin, a highly specific activator of adenylate cyclase, produced both delay and advance phase shifts of the circadian rhythm recorded from the isolated eye of the marine mollusk Aplysia. The phase dependence of the response to forskolin was identical to that with serotonin, which also stimulates adenylate cyclase in the eye. The ability of agents to activate adenylate cyclase in homogenates was correlated with their ability to shift the phase of the circadian oscillator. These results along with earlier findings show that adenosine 3',5'-monophosphate mediates the effect of serotonin on the rhythm and regulates the phase of the circadian pacemaker in the eye of Aplysia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eskin, A -- Takahashi, J S -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):82-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6298939" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Monophosphate/physiology ; Adenylyl Cyclases/*physiology ; Animals ; Aplysia/physiology ; *Circadian Rhythm/drug effects ; Colforsin ; Cyclic AMP/physiology ; Diterpenes/pharmacology ; Eye/drug effects ; Ocular Physiological Phenomena ; Serotonin/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Serotonin shifts the phase of the circadian rhythm from the Aplysia eye (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: A putative neurotransmitter, serotonin, may be used to transmit temporal information in the eye of Aplysia, because it can shift the phase of the circadian rhythm of spontaneous optic nerve impulses from the eye and the eye contains a significant quantity of serotonin. Serotonin acts either directly on the cell, or cells, containing the circadian pacemaker or on cells electronically coupled to the pacemaker cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Corrent, G -- McAdoo, D J -- Eskin, A -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):977-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/309655" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Hydroxytryptophan/pharmacology ; Animals ; Aplysia ; Circadian Rhythm/*drug effects ; Dopamine/pharmacology ; Eye/metabolism ; In Vitro Techniques ; *Ocular Physiological Phenomena ; Serotonin/metabolism/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Perspective usage estimation of Volga region combustible shale as a power generating fuel alternative (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-05-23
    Description: A comprehensive study of combustible shale, common within Tatarstan and Ulyanovsk region, is carried out. The rocks physicochemical parameters are found to meet the power generating fuels requirements. The predictive estimate of ash products properties of combustible shale burning is held. Minding furnace process technology it is necessary to know mineral and organic components behavior when combustible shale is burnt. Since the first will determine slagging properties of energy raw materials, the second – its calorific value. In consideration of this the main research methods were X-ray, thermal and X-ray fluorescence analyses. Summing up the obtained results, we can draw to the following conclusions: 1. The combustible shale in Tatarstan and the Ulyanovsk region has predominantly low calorific value (Q b d = 5-9 MJ/kg). In order to enhance its efficiency and to reduce cost it is possible to conduct rocks burning together with some othe...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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  • 8
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    Dissolved Air Flotation with Saturation of Liquid in Spray-Type Saturator (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-12-01
    Description: A new method of dissolved air (pressure) flotation with the spraying of liquid is presented in the paper. The liquid to be treated is sprayed in the saturator with a hydraulic nozzle which makes it possible to increase the contact surface between the liquid and the gas in comparison with the traditional sparged-air saturator system. The proposed method increases the gas content of the liquid entering the flotation unit for treatment. The paper presents the results of experimental research in terms of the efficiency of liquid saturation in a pressure vessel using whirl and spiral nozzles. The volumetric method was used to determine the amount of air released during the dissolved air flotation based on which the sparging rate was calculated. It is shown that, when the liquid is sprayed, the amount of dissolved air increases by an average of 33% compared to a sparged-air pressure vessel. The sparging rate increases with the increase of saturation pressure and essentially depends on...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 9
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    Centrifugal Pump Effect on Average Particle Diameter of Oil-Water Emulsion (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-11-30
    Description: In this paper we review the process of oil-water emulsion particles fragmentation in a turbulent flow created by a centrifugal pump. We examined the influence of time necessary for oil-water emulsion preparation on the particle size of oil products and the dependence of a centrifugal pump emulsifying capacity on the initial emulsion dispersion. The investigated emulsion contained the brand fuel oil M-100 and tap water; it was sprayed with a nozzle in a gas-water flare. After preparation of the emulsion, the centrifugal pump was turned on and the emulsion samples were taken before and after the pump passing in 15, 30 and 45 minutes of spraying. To determine the effect the centrifugal pump has on the dispersion of the oil-water emulsion, the mean particle diameter of the emulsion particles was determined by the optical and microscopic method before and after the pump passing. A dispersion analysis of the particles contained in the emulsion was carried out by a laser diffraction an...
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 10
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    Oxidation Behavior of Light Crude Oil and Its SARA Fractions Characterized by TG and DSC Techniques: Differences and Connections (2017)
    American Chemical Society (ACS)
    Details
    Publication Date: 2017-12-16
    Description: Energy & Fuels DOI: 10.1021/acs.energyfuels.7b02377
    Print ISSN: 0887-0624
    Electronic ISSN: 1520-5029
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Process Engineering, Biotechnology, Nutrition Technology
    Published by American Chemical Society (ACS)
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