Publication Date:
2011-01-22
Description:
Intracellular pathogens such as Listeria monocytogenes subvert cellular functions through the interaction of bacterial effectors with host components. Here we found that a secreted listerial virulence factor, LntA, could target the chromatin repressor BAHD1 in the host cell nucleus to activate interferon (IFN)-stimulated genes (ISGs). IFN-lambda expression was induced in response to infection of epithelial cells with bacteria lacking LntA; however, the BAHD1-chromatin associated complex repressed downstream ISGs. In contrast, in cells infected with lntA-expressing bacteria, LntA prevented BAHD1 recruitment to ISGs and stimulated their expression. Murine listeriosis decreased in BAHD1(+/-) mice or when lntA was constitutively expressed. Thus, the LntA-BAHD1 interplay may modulate IFN-lambda-mediated immune response to control bacterial colonization of the host.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lebreton, Alice -- Lakisic, Goran -- Job, Viviana -- Fritsch, Lauriane -- Tham, To Nam -- Camejo, Ana -- Mattei, Pierre-Jean -- Regnault, Beatrice -- Nahori, Marie-Anne -- Cabanes, Didier -- Gautreau, Alexis -- Ait-Si-Ali, Slimane -- Dessen, Andrea -- Cossart, Pascale -- Bierne, Helene -- 233348/European Research Council/International -- New York, N.Y. -- Science. 2011 Mar 11;331(6022):1319-21. doi: 10.1126/science.1200120. Epub 2011 Jan 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Pasteur, Unite des Interactions Bacteries Cellules, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21252314" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Cell Line
;
Cell Line, Tumor
;
Cell Nucleus/metabolism
;
Chromatin/*metabolism
;
Chromosomal Proteins, Non-Histone/*metabolism
;
Down-Regulation
;
Gene Expression Profiling
;
Gene Expression Regulation
;
Host-Pathogen Interactions
;
Humans
;
Interferons/genetics/immunology/*metabolism
;
Interleukins/genetics/immunology/*metabolism
;
Listeria monocytogenes/genetics/metabolism/*pathogenicity
;
Listeriosis/*immunology/microbiology
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
Signal Transduction
;
Virulence Factors/chemistry/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink